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Table S1. Odds ratios for current asthma, wheeze and allergic sensitization in children up to 4 years in relation to early maternal smoking*.

Table S2. Odds Ratios for current asthma, early-onset wheeze, late onset wheeze and allergic sensitization* in children followed up to 4 years: main genetic effects of TNF, GSTP1 and ADRB2 SNPs.

Table S3. Adjusted Odds Ratios for early-onset wheeze in children followed up to 4 years: effect modification of early maternal smoking exposure* by TNF, GSTP1 and ADRB2 gene variants.

Table S4. Odds Ratios for current asthma, late-onset wheeze and sensitization in children followed up to 4 years: effect modification of early maternal smoking exposure* by TNF, GSTP1 and ADRB2 gene variants.

Table S5. Odds Ratios for transient and persistent wheeze in children followed up to 4 years: effect modification of early maternal smoking exposure* by TNF and GSTP1 gene variants.

Table S6. Odds ratios for early-onset wheeze in children followed up to 4 years in relation to extent of maternal smoking during pregnancy (non smoking, moderate: 1–9 cigarettes per day, and high:>9 cigarettes per day*), stratified by genetic variation in the TNF -857 (rs1799724) SNP.

Figure S1. Block structure and correlation of the SNPs in the TNF gene (A), GSTP1 gene (B), and ADRB2 gene (C). The numbers in each box correspond to the pairwise correlation coefficient r2 between respective SNPs. Defining the block structure was based on the linkage disequilibrium coefficient D' using Haploview (Solid spine of LD).

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