SEARCH

SEARCH BY CITATION

Figure S1. H&E-stained lung sections. Original magnification ×100. Perivascular and peribronchial inflammation was evaluated as (a) mild, (b) moderate, and (c) severe. (a) Mild peribronchial inflammation (centre) surrounded by clear alveoli and cross-sectioned bronchioles (bottom left, right). (b) Moderate peribronchial inflammation surrounding bronchiole (top right, bottom right) and moderate alveolar inflammation. (c) Severe perivascular and peribronchial inflammation with bronchial epithelial hypertrophy (centre, centre right). Images represent typical pathology at each grade.

Figure S2. BPZE1 challenge prior to OVA sensitisation decreases airway hyperresponsiveness to sensitising allergen. Airway responsiveness was assessed on day 37 by methacholine induced airflow obstruction from conscious mice using whole-body plethysmography in conjunction with the BioSystem XA software (Buxco Electronics, USA) as previously described [16]. (a) Non-sensitised (), OVA-sensitised (), BPSM infected+OVA sensitisation () and BPZE1 challenge+OVA sensitisation (). (b) Nonsensitised (Control ), OVA-sensitised (), non-sensitised BPSM infected () and nonsensitised BPZE1 challenge (). Results are expressed as mean enhanced pause (PenH)±S.E.M. Where no error bars are visible, error bars are shorter than the size of the data point symbol. Data points represent the mean PenH from eight mice in this case.

Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article.

FilenameFormatSizeDescription
CEA_3459_sm_suppinfo.pdf2185KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.