Plasma brain-derived neurotrophic factor levels are associated with clinical severity in school age children with asthma
Article first published online: 28 SEP 2010
© 2010 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 40, Issue 12, pages 1755–1759, December 2010
How to Cite
Müller, G. C., Pitrez, P. M., Teixeira, A. L., Pires, P. S., Jones, M. H., Stein, R. T. and Bauer, M. E. (2010), Plasma brain-derived neurotrophic factor levels are associated with clinical severity in school age children with asthma. Clinical & Experimental Allergy, 40: 1755–1759. doi: 10.1111/j.1365-2222.2010.03618.x
- Issue published online: 9 NOV 2010
- Article first published online: 28 SEP 2010
- Submitted 9 March 2010; revised 19 August 2010; accepted 20 August 2010
- inflammatory cytokines;
- severe asthma
Background Asthma is characterized by chronic inflammation of the airways with significant changes in leucocyte trafficking, cellular activation and tissue remodelling. Brain-derived neurotrophic factor (BDNF) has been involved with asthma and allergic diseases but its role as a severity marker in paediatric asthma has not been clinically assessed.
Objectives To evaluate plasma BDNF and inflammatory markers in order to address their relationships with disease severity in children (6–15 years) with controlled persistent asthma.
Methods Children with persistent asthma were selected and lung function and skin prick tests were performed in all patients. Plasma BDNF levels and various inflammatory markers (CCL3, CCL11, CCL22, CCL24, CXCL8, CXCL9, CXCL10, soluble TNF receptors) were assessed by ELISAs.
Results Subjects with moderate and severe asthma had higher BDNF levels than mild asthma and controls (P<0.001). The chemokines studied and soluble TNF receptors did not differ between the studied groups.
Conclusion and Clinical Relevance Our results indicate BDNF as a potential biomarker for clinical severity in children with asthma.
Cite this as: G. C. Müller, P. M. Pitrez, A. L. Teixeira, P. S. Pires, M. H. Jones, R. T. Stein and M. E. Bauer, Clinical & Experimental Allergy, 2010 (40) 1755–1759.