Clinical & Experimental Allergy

Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents

Authors

  • S. Zhang,

    1. Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Children's Memorial Research Center, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    2. Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou, China
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    • *Contributed equally.

  • X. Liu,

    1. Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Children's Memorial Research Center, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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    • *Contributed equally.

  • J. S. Kim,

    1. Department of Pediatrics, Division of Allergy and Immunology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • F. Ouyang,

    1. Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Children's Memorial Research Center, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • B. Wang,

    1. Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Children's Memorial Research Center, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Z. Li,

    1. Institute for Biomedicine, Anhui Medical University, Hefei, China
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  • G. Tang,

    1. Institute for Biomedicine, Anhui Medical University, Hefei, China
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  • X. Liu,

    1. Institute for Biomedicine, Anhui Medical University, Hefei, China
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  • X. Xu,

    1. Center for Population Genetics, School of Public Health, University of Illinois, Chicago, IL, USA
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  • J. A. Pongracic,

    1. Department of Pediatrics, Division of Allergy and Immunology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • X. Wang

    1. Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Children's Memorial Research Center, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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Correspondence:
Xiaobin Wang, Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Children's Memorial Research Center, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
E-mail: xbwang@childrensmemorial.org

Abstract

Cite this as: S. Zhang, X. Liu, J. S. Kim, F. Ouyang, B. Wang, Z. Li, G. Tang, X. Liu, X. Xu, J. A. Pongracic and X. Wang, Clinical & Experimental Allergy, 2011 (41) 547–555.

Summary

Background Both long and short sleep duration have been associated with obesity, cardiovascular disease, and diabetes. However, there have been no previous studies investigating the potential relationship between altered sleep duration and allergen sensitization.

Objective To explore the association between sleep duration and sensitization to food and aeroallergens.

Methods This study includes 1534 rural Chinese adolescent twins aged 12–21 years who completed standard sleep questionnaires and skin prick tests (SPTs) to nine food and five aeroallergens. Total sleep time was defined as the interval from bedtime to wake-up time minus sleep latency. Sensitization was defined as having at least one positive SPT.

Results Compared with individuals with the highest (third) tertile of sleep duration, those who slept less were more likely to be sensitized to any food allergen with odds ratios (ORs) of 1.9 [95% confidence interval (CI): 1.3–2.7] and 1.4 (95% CI: 1.0–1.9) for the first and second tertiles (trend test Ptrend=3 × 10−4), respectively. The corresponding ORs for sensitization to any aeroallergen were 1.5 (95% CI: 1.1–2.0) and 1.3 (95% CI: 1.0–1.7) (Ptrend=8 × 10−3). These associations were independent of percent body fat. In addition, we observed a significant dose–response association between the number of positive SPTs and percentage of shortest sleep duration (first tertile) (Ptrend=1 × 10−3).

Conclusions and Clinical Relevance In this sample of relatively lean rural Chinese adolescents, we found that short sleep duration was associated with increasing risk of sensitization to food and aeroallergens, independent of percent body fat. Longitudinal studies are needed to further determine the temporal and causal relationships. If short sleep duration indeed is one of the risk factors for allergic sensitization, the global burden of allergic diseases could be dramatically reduced by providing appropriate guidance on sleep duration for youth.

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