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Clonorchis sinensis infection is positively associated with atopy in endemic area

Authors

  • M-H Choi,

    1. Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
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    • *Contributed equally.

  • Y-S Chang,

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
    2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyonggi, Korea
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    • *Contributed equally.

  • M. K. Lim,

    1. National Cancer Center, National Cancer Control Research Institute, Goyang, Gyonggi, Korea
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  • Y. M. Bae,

    1. Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
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  • S-T Hong,

    1. Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
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  • J-K Oh,

    1. National Cancer Center, National Cancer Control Research Institute, Goyang, Gyonggi, Korea
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  • E. H. Yun,

    1. National Cancer Center, National Cancer Control Research Institute, Goyang, Gyonggi, Korea
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  • M-J Bae,

    1. National Cancer Center, National Cancer Control Research Institute, Goyang, Gyonggi, Korea
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  • H-S Kwon,

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
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  • S-M Lee,

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
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  • H-W Park,

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
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  • K-U Min,

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
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  • Y-Y Kim,

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
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  • S-H Cho

    1. Department of Internal Medicine, Seoul National University College of Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea
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Correspondence:
S-H Cho, Department of Internal Medicine, Seoul National University College of Medicine, Institute of Endemic Diseases, Seoul National University Medical Research Center, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea.
E-mail: shcho@plaza.snu.ac.kr

Summary

Background Epidemiologic studies have suggested that helminth infections play a protective role against allergy; this inverse association, however, has not been consistent. Clonorchis sinensis, the liver fluke of human, is prevalent in the Far East. The association between C. sinensis infection and allergy has not yet been reported.

Objective We evaluated the association between clonorchiasis and atopy or allergic diseases in adults in endemic areas of clonorchiasis.

Methods A total of 1116 subjects (males 419, females 697; age range, 30–86; mean age=61 years) were recruited from two endemic areas of C. sinensis in Korea. Clonorchiasis was confirmed by stool examination. Allergic symptoms were evaluated with a modified ISAAC questionnaire, and atopy was defined by skin prick test for common inhalant allergens. Total serum IgE and C. sinensis-specific IgE level was measured by ELISA and methacholine bronchial provocation test was performed to evaluate airway hyperresponsiveness (AHR).

Results Clonorchiasis was positively associated with atopy [odds ratio (OR), 1.856; 95% confidence interval (CI), 1.199–2.873] and high levels of total serum IgE (OR, 1.455; 95% CI, 1.050–2.016). Higher association with clonorchiasis was shown in subjects who showed both atopy and high total serum IgE levels (OR, 2.540; 95% CI, 1.448–4.455). Clonorchiasis had no association with wheezing, AHR, asthma or allergic rhinitis.

Conclusion and Clinical Relevance Clonorchiasis was positively associated with atopy in adults in endemic area.

Cite this as: M-H Choi, Y-S Chang, M. K. Lim, Y. M. Bae, S-T Hong, J-K Oh, E. H. Yun, M-J Bae, H-S Kwon, S-M Lee, H-W Park, K-U Min, Y-Y Kim and S-H Cho, Clinical & Experimental Allergy, 2011 (41) 697–705.

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