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Clinical & Experimental Allergy

Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria

Authors

  • K. Rössing,

    1. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
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  • N. Novak,

    1. Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
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  • S. Mommert,

    1. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
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  • F. Pfab,

    1. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    2. Department of Dermatology and Allergy, Technische Universität München, München, Germany
    3. Helmholtz Center Munich, Division of Environmental Dermatology and Allergy, Technische Universität München, München, Germany
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  • M. Gehring,

    1. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
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  • B. Wedi,

    1. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
    2. Department of Dermatology and Allergy, Technische Universität München, München, Germany
    3. Helmholtz Center Munich, Division of Environmental Dermatology and Allergy, Technische Universität München, München, Germany
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  • A. Kapp,

    1. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
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  • U. Raap

    1. Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany
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Prof. Dr. med. Ulrike Raap, MD, Department of Dermatology and Allergy, Hannover Medical School, Ricklinger Str. 5, 30449 Hannover, Germany.
E-mail: Raap.Ulrike@mh-hannover.de

Summary

Background Chronic spontaneous urticaria is triggered by many direct and indirect aggravating factors including autoreactive/autoimmune mechanisms, infections, non-allergic and pseudoallergic intolerance reactions. However, the role of neuroimmune mechanisms in chronic spontaneous urticaria so far is unclear.

Objective Thus, we wanted to address the regulation of the neurotrophin brain-derived neurotrophic factor (BDNF) in serum and inflammatory skin of patients with chronic spontaneous urticaria in comparison to subjects with healthy skin.

Methods Fifty adult patients with chronic spontaneous urticaria and 23 skin-healthy subjects were studied. Chronic spontaneous urticaria was defined as recurrent weals for more than 6 weeks. Autologous serum skin test was performed in all patients with chronic spontaneous urticaria and BDNF serum levels were analysed by enzyme immunoassay in all subjects. Furthermore, skin biopsies were taken from weals of eight patients with chronic spontaneous urticaria as well as from healthy skin of eight controls to evaluate the expression of BDNF and its receptors including tyrosine kinase (trk) B and pan-neurotrophin receptor p75NTR by immunohistochemistry.

Results BDNF serum levels were detectable in all subjects studied. However, BDNF levels were significantly higher in patients with chronic spontaneous urticaria compared to non-atopic skin-healthy controls (P<0.001). Furthermore, epidermal and dermal expression of BDNF and epidermal expression of p75NTR was significantly higher in patients with chronic spontaneous urticaria compared with controls (P<0.05–0.001). There was no difference with regard to the expression of trkB between chronic spontaneous urticaria and controls and no difference in BDNF serum levels between autologous serum skin test-positive (n=23) and -negative (n=27) patients with chronic spontaneous urticaria.

Conclusions and Clinical Relevance This study shows that BDNF is increased in serum and diseased skin of patients with chronic spontaneous urticaria, suggesting a role for neurotrophins in the pathophysiology of this chronic inflammatory skin disease. Further studies are needed to address the functional role of BDNF on key target effector cells in chronic spontaneous urticaria to establish new therapeutic implications.

Cite this as: K. Rössing, N. Novak, S. Mommert, F. Pfab, M. Gehring, B. Wedi, A. Kapp and U. Raap, Clinical & Experimental Allergy, 2011 (41) 1392–1399.

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