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Figure S1. Study flow diagram showing identification in the GPRD of patients aged 5–60 years with asthma who received a first prescription or first increase in dose of ICS as EF HFA-BDP or CFC-BDP between January 1, 1998, and June 30, 2006 (full study period, January 1997 through June 2007).

BAI, breath-actuated inhaler; CFC-BDP, chlorofluorocarbon beclometasone; COPD, chronic obstructive pulmonary disease; DPI, dry powder inhaler; EF HFA, extrafine hydrofluoroalkane; ICS, inhaled corticosteroid; pMDI, pressurised metered-dose inhaler

Figure S2. Selection of eligible patients in the database: matching of the cohorts (A) initiating ICS therapy (initiation population) or (B) receiving their first increase in dose of ICS (step-up population) as EF HFA-BDP or CFC-BDP by metered-dose inhaler.

CFC-BDP, chlorofluorocarbon beclometasone; COPD, chronic obstructive pulmonary disease; DPI, dry powder inhaler; EF HFA, extrafine hydrofluoroalkane; ICS, inhaled corticosteroid; SABA, short-acting β2 agonist

Table S1. Unmatched analysis: baseline characteristics of patients initiating ICS by pMDI and those receiving an increased dose of ICS by pMDI.

Table S2. Unmatched analysis: outcomes for patients initiating ICS and those receiving an increased dose of ICS.

Table S3. Unmatched analysis: odds ratios (95% CI) for measures of asthma control and change in therapy, and rate ratios (95% CI) for exacerbations, in the EF HFA-BDP cohorts of initiation and step-up populations during the outcome year, with the CFC-BDP cohort set as the reference group (OR = 1.0).

Table S4. Unmatched analysis: change in therapy by type for patients initiating ICS and those receiving an increased dose of ICS.

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