Get access
Clinical & Experimental Allergy

Childhood overweight and asthma symptoms, the role of pro-inflammatory proteins

Authors

  • M. B. M. Bekkers,

    1. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands
    2. Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
    Search for more papers by this author
  • B. Brunekreef,

    1. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands
    2. Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Search for more papers by this author
  • J. C. de Jongste,

    1. Department of Paediatrics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands
    Search for more papers by this author
  • M. Kerkhof,

    1. Department of Epidemiology and Bioinformatics, University of Groningen, Groningen, The Netherlands
    Search for more papers by this author
  • H. A. Smit,

    1. Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Search for more papers by this author
  • D. S. Postma,

    1. Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Search for more papers by this author
  • U. Gehring,

    1. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands
    Search for more papers by this author
  • A. H. Wijga

    1. Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
    Search for more papers by this author


Marga Bekkers, Centre for Prevention and Health Services Research (pb 101), National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. E-mail: marga.bekkers@rivm.nl

Summary

Background Systemic inflammation is suggested as a mechanism by which overweight might induce asthma. However, few studies have linked childhood overweight, inflammation and asthma.

Objective To study the association between body mass index (BMI), asthma symptoms and pro-inflammatory proteins.

Methods High-sensitivity C-reactive protein (hs-CRP), complement factor 3 (C3) and 4 (C4) concentrations, and body weight and height were available for 359 4-year-old children participating in the Prevention and Incidence of Asthma and Mite Allergy birth cohort study. Data on asthma symptoms were obtained by yearly questionnaires. Logistic regression and generalized estimating equations were used to analyse the cross-sectional and prospective associations between BMI, asthma symptoms and pro-inflammatory proteins.

Results BMI was associated with asthma symptoms {odds ratio [OR] 1.43 [95% confidence interval (CI): 1.08–1.88] per BMI standard deviation scores [SDS]}. The inclusion of hs-CRP, C3 and C4 in the statistical models did not change this association. C3 was cross-sectionally associated with frequent asthma symptoms [OR per interquartile range of C3: 1.97 (95% CI: 1.20–3.24)] and prospectively with asthma symptoms [OR: 1.48 (95%CI: 1.04–2.09)], independent of BMI SDS.

Conclusions and Clinical Relevance We showed no evidence for a role of hs-CRP, C3 and C4 in the association between BMI and asthma symptoms. C3 concentrations were associated with (frequent) asthma symptoms, independent of BMI.

Cite this as: M. B. M. Bekkers, B. Brunekreef, J. C. de Jongste, M. Kerkhof, H. A. Smit, D. S. Postma, U. Gehring and A. H. Wijga, Clinical & Experimental Allergy, 2012 (42) 95–103.

Get access to the full text of this article

Ancillary