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cea3882-sup-0001-TableS1.docWord document209KTable S1. Clinical characteristics of individuals with data available at all three time-points*.
cea3882-sup-0002-TableS2.docWord document209KTable S2. Cytokine production by PHA-stimulated total MNC and CD25-depleted MNC at 1 year.
cea3882-sup-0003-FigureS1.docWord document209KFigure S1. Immunomodulatory T cell numbers and their suppressive function at birth are not associated with allergic sensitization at 1 and 2 years of age. Spearman correlations evaluated the relation of SI, and the proportions of CD4+CD25bright and CD4+CD25+FoxP3+ cells at birth to clinical outcomes at age 1 (A) and 2 (B). Correlation coefficients (circles) and direction of associations are indicated. Significant associations (P < 0.05) are highlighted by closed circles. P-values for each association are listed on right of each panel.
cea3882-sup-0004-FigureS2.docWord document209KFigure S2. Increases in CD4+CD25+CD45RO+ and CD4+CD25+FoxP3+CD45RO+ cell numbers at age 2 were positively associated with allergic sensitization and disease at age 2. Spearman correlations evaluated the relationship between proportions of CD4+CD25+CD45RO+ and CD4+CD25+FoxP3+CD45RO+ cells at age 2, to clinical outcomes at age 2. Correlation coefficients (circles) and direction of associations are indicated. Significant associations (P < 0.05) are highlighted by closed circles. P-values for each association are listed on right of each panel.
cea3882-sup-0005-FigureS3.docWord document209KFigure S3. Increases in CD25+ T cell suppressive capacity from birth to age 1 were negatively associated with allergic sensitization at age 1 and age 2. Spearman correlations evaluated the relation of longitudinal changes in suppressive index (SI) from birth to 1 year, with clinical outcomes at age 1 and age 2. Correlation coefficients (circles) and direction of associations are indicated. Significant associations (P < 0.05) are highlighted by closed circles. P-values for each association are listed on right of each panel.
cea3882-sup-0006-FigureS4.docWord document209KFigure S4. Increases in CD4+CD25+FoxP3+ cell numbers from age 1 to age 2 were positively associated with allergic sensitization and disease at 2 years of age. Spearman correlations evaluated the relation of longitudinal changes in the proportions of CD4+CD25+FoxP3+ cells from age 1 to age 2, with clinical outcomes at age 2 years. Correlation coefficients (circles) and direction of associations are indicated. Significant associations (P < 0.05) are highlighted by closed circles. P-values for each association are listed on right of each.

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