Get access
Clinical & Experimental Allergy

Results of drug hypersensitivity evaluations in a large group of children and adults

Authors

  • M. Rubio,

    1. Allergy Department and INSERM U657, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Search for more papers by this author
  • P.-J. Bousquet,

    1. Allergy Department and INSERM U657, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    2. Département d'Epidemiologie Clinique, Biostatistique, Santé Publique et Information Médicale, Hôpital Carémeau, University Hospital of Nîmes, France
    Search for more papers by this author
  • E. Gomes,

    1. Serviço de Imunoalergologia, Hospital Maria Pia, Porto, Portugal
    Search for more papers by this author
  • A. Romano,

    1. Complesso Integrato Columbus, Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Rome, Italy
    2. IRCCS Oasi Maria S.S., Troina, Italy
    Search for more papers by this author
  • P. Demoly

    Corresponding author
    • Allergy Department and INSERM U657, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Search for more papers by this author

Correspondence:

Pascal Demoly, Allergy Department and INSERM U657, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France.

E-mail: pascal.demoly@inserm.fr

Summary

Background

Proven IgE or T-cell mediated drug hypersensitivity reactions (DHRs) seem less common in children compared with adults. However, this has never been proved by data.

Objective

To determine and compare proven DHR prevalence in children and adults.

Methods

Using the DAHD (DrugAllergy andHypersensitivityDatabase) cohort, children with proven DHRs were compared with adults. The international EAACI-ENDA recommendations were followed. Patients were divided into four groups: index reaction and test during childhood (C/C), index reaction at childhood and test at adulthood (C/A), index reactions at childhood and adulthood and test at adulthood (CA/A), index reaction and test at adulthood (A/A).

Results

A total of 3275 patients (67.9% female), comprising a total of 4370 patient-episodes, were evaluated (74.5% belonged to the A/A group). Prevalence of positive tests was 15.2% (95%CI, 14.1–16.2) for all tested classes, 10.6% (8.3–13.0) for C/C, 10.6% (7.5–13.6) for C/A, 22.1% (12.8–31.3) for CA/A and 16.5% (15.2–17.8) for A/A. The prevalence was lower in group C/C compared with groups A/A (P < 0.0001) and CA/A (P = 0.003). It was also lower in group C/A compared with the two latter groups (respectively P = 0.003 and P = 0.005). Significant differences were found for maculopapular exanthemas only, and not for urticaria/angiœdema and anaphylaxis. The difference was mainly observed with β-lactams and not for NSAIDs.

Conclusion and Clinical Relevance

Suspicions of DHRs are less likely to be confirmed in children.

Get access to the full text of this article

Ancillary