Erlewyn-Lajeunesse M, Lucas JSA and Warner JO. Influenza immunization in egg allergy: an update for the 2011–2012 season. Clin Exp Allergy 2011; 41: 1367–70.
Two vaccines that we recommended based on their very low egg content have now been shown to contain higher amounts of egg protein, unsuitable for egg allergic individuals. Immunisers should check the Summary of Product Characteristics of any vaccine before administration.
The correct table is shown below:
Table 2. Summary of guidance for the 2011/2012 season in the UK
|Type||Seasonal 2011/2012||Manufacturer||Age indications||Ovalbumin content (mcg/mL)||Lower risk egg allergy||Higher risk egg allergy|
|Egg free||Preflucel||Baxter||From 18 years||No ovalbumin||Single dose in Primary care||Single dose in Primary Care|
|Very low egg < 0.12 mcg/mL||Inactivated Influenza||Sanofi Pasteur MSD||From 6 months||<0.048||Single dose in Primary Care*||Single dose in Hospital*|
|Viroflu||Crucell UK||From 6 months||<0.1|
|Fluarix||GlaxoSmithKline||From 6 months||<0.1|
|Intanza 9 mcg**||Sanofi Pasteur MSD||From 18 to 59 years||<0.048|
|Intanza 15 mcg**||Sanofi Pasteur MSD||From 60 years||<0.048|
|Low egg < 1.2 mcg/mL||Agrippal||Novartis||From 6 months||<0.2||Single dose in Hospital*||Split dose in Hospital*|
|Imuvac||Abbott||From 6 months||<0.2|
|Imuvac||MASTA||From 6 months||<0.2|
|Influvac||Abbott||From 6 months||<0.2|
|Not appropriate > 1.2 mcg/mL||CSL Inactivated Influenza||Pfizer||From 5 years||<2 mcg|
|Enzira Fluvirin||Pfizer Novartis||From 5 years From 4 years||<2 mcg <2.0||Do not use in egg allergy||Do not use in egg allergy|
Table based upon vaccine data from Department of Health . *Hospital refers to any healthcare setting used to treating anaphylaxis with a physician in attendance. A single dose is a single injection of the full vaccine dose normally 0.5 mL, a split dose refers to an initial dose of 1/10th, that is, 0.05 mL followed by the remaining 9/10th at an interval of 30 min. **Intanza is an intradermal product and the safety of this route of administration has not been established in egg allergy.