Function and mechanisms of TSLP/TSLPR complex in asthma and COPD
Article first published online: 14 DEC 2011
© 2011 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 42, Issue 7, pages 994–1005, July 2012
How to Cite
N. S. Redhu and A. S. Gounni, Clinical & Experimental Allergy, 2012 (42) 994–1005.
- Issue published online: 15 JUN 2012
- Article first published online: 14 DEC 2011
- Manuscript Accepted: 9 NOV 2011
- Manuscript Revised: 6 NOV 2011
- Manuscript Received: 6 SEP 2011
- Canadian Institutes of Health Research (CIHR)
- Manitoba Research Chairs programme
- Canadian Thoracic Society-Canada Lung Association (CTS-CLA)
Thymic stromal lymphopoietin (TSLP) is a key pro-allergic cytokine that has recently been linked to chronic airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). High levels of TSLP were detected in bronchial mucosa of asthma and COPD patients suggesting TSLP's biological role beyond a signature ‘Th2-favoring’ or ‘pro-allergic cytokine’. Besides inflammatory cells, airway structural cells produce and are targets of TSLP suggesting a potential autocrine loop that may have a profound effect on local inflammatory response and airway remodelling. This review sums up diverse mechanisms that mediate TSLP/TSLP receptor-signalling network in chronic airway diseases.