Maternal intestinal flora and wheeze in early childhood
Article first published online: 23 MAY 2012
© 2011 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 42, Issue 6, pages 901–908, June 2012
How to Cite
Cite this as: N. E. Lange, J. C. Celedón, E. Forno, N. P. Ly, A. Onderdonk, L. Bry, M. L. Delaney, A. M. DuBois, D. R. Gold, S. T. Weiss and A. A. Litonjua, Clinical & Experimental Allergy, 2012 (42), 901–908.
- Issue published online: 23 MAY 2012
- Article first published online: 23 MAY 2012
- Accepted manuscript online: 28 DEC 2011 05:37AM EST
- Manuscript Accepted: 19 DEC 2011
- Manuscript Revised: 20 NOV 2011
- Manuscript Received: 1 SEP 2011
- Harvard National Institute of Environmental Health Sciences Center
- NIH. Grant Number: HL07427
- infant wheeze;
- intestinal flora;
- maternal flora;
Increasing evidence links altered intestinal flora in infancy to eczema and asthma. No studies have investigated the influence of maternal intestinal flora on wheezing and eczema in early childhood.
To investigate the link between maternal intestinal flora during pregnancy and development of wheeze and eczema in infancy.
A total of 60 pregnant women from the Boston area gave stool samples during the third trimester of their pregnancy and answered questions during pregnancy about their own health, and about their children's health when the child was 2 and 6 months of age. Quantitative culture was performed on stool samples and measured in log10colony-forming units (CFU)/gram stool. Primary outcomes included infant wheeze and eczema in the first 6 months of life. Atopic wheeze, defined as wheeze and eczema, was analysed as a secondary outcome.
In multivariate models adjusted for breastfeeding, day care attendance and maternal atopy, higher counts of maternal total aerobes (TA) and enterococci (E) were associated with increased risk of infant wheeze (TA: OR 2.32 for 1 log increase in CFU/g stool [95% CI 1.22, 4.42]; E: OR 1.57 [95% CI 1.06, 2.31]). No organisms were associated with either eczema or atopic wheeze.
Conclusions and Clinical Relevance
In our cohort, higher maternal total aerobes and enterococci were related to increased risk of infant wheeze. Maternal intestinal flora may be an important environmental exposure in early immune system development.