Fish oil supplementation in early infancy modulates developing infant immune responses
Article first published online: 16 JUL 2012
© 2012 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 42, Issue 8, pages 1206–1216, August 2012
How to Cite
N. D.'Vaz, S. J. Meldrum, J. A. Dunstan, T. F. Lee-Pullen, J. Metcalfe, B. J. Holt, M. Serralha, M. K. Tulic, T. A. Mori and S. L. Prescott, Clinical & Experimental Allergy, 2012 (42) 1206–1216.
- Issue published online: 16 JUL 2012
- Article first published online: 16 JUL 2012
- Accepted manuscript online: 8 MAY 2012 09:51AM EST
- Manuscript Accepted: 23 APR 2012
- Manuscript Revised: 20 APR 2012
- Manuscript Received: 7 JAN 2012
- National Health and Medical Research Council (NHMRC)
- Princess Margaret Hospital Foundation
- The Asthma Foundation of Western Australia
- fish oil supplementation;
- omega 3 Polyunsaturated fatty acids.
Maternal fish oil supplementation during pregnancy has been associated with altered infant immune responses and a reduced risk of infant sensitization and eczema.
To examine the effect of early postnatal fish oil supplementation on infant cellular immune function at 6 months of age in the context of allergic disease.
In a double-blind randomized controlled trial (ACTRN12606000281594), 420 infants of high atopic risk received fish oil [containing 280 mg docosahexaenoic acid (DHA) and 110 mg eicosapentanoic acid (EPA)] or control oil daily from birth to 6 months. One hundred and twenty infants had blood collected at 6 months of age. Fatty acid levels, induced cytokine responses, T cell subsets and monocyte HLA-DR expression were assessed at 6 months of age. Infant allergies were assessed at 6 and 12 months of age.
DHA and EPA levels were significantly higher in the fish oil group and erythrocyte arachidonic acid (AA) levels were lower (all P < 0.05). Infants in the fish oil group had significantly lower IL-13 responses (P = 0.036) to house dust mite (HDM) and higher IFNγ (P = 0.035) and TNF (P = 0.017) responses to phytohaemaglutinin (PHA). Infants with relatively high DHA levels had lower Th2 responses to allergens including lower IL-13 to β-lactoglobulin (BLG) (P = 0.020), and lower IL-5 to BLG (P = 0.045).
Conclusions and clinical relevance
Postnatal fish oil supplementation increased infant n-3 polyunsaturated fatty acid (PUFA) levels and associated with lowered allergen-specific Th2 responses and elevated polyclonal Th1 responses. Our results add to existing evidence of n-3 PUFA having immunomodulatory properties that are potentially allergy-protective.