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Clinical & Experimental Allergy

Allergic rhinitis is associated with otitis media with effusion: a birth cohort study

Authors

  • E. Kreiner-Møller,

    1. COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    2. The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
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  • B. L. K. Chawes,

    1. COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    2. The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
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  • P. Caye-Thomasen,

    1. Department of Oto-rhino-laryngology, Head and Neck Surgery, Copenhagen University Hospital Rigshospitalet, Gentofte, Denmark
    2. Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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  • K. Bønnelykke,

    1. COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    2. The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
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  • H. Bisgaard

    Corresponding author
    1. The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
    • COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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Correspondence:

Hans Bisgaard

COPSAC; Copenhagen Prospective Studies on Asthma in Childhood

Faculty of Health Sciences, University of Copenhagen

The Danish Pediatric Asthma Center

Copenhagen University Hospital, Gentofte

Ledreborg Alle 34; 2820 Gentofte; Denmark

E-mail: bisgaard@copsac.com

Abstract

Background

Childhood otitis media with effusion is a common disease and a link to allergic diseases has been suggested.

Objective

To investigate the association between atopic disease and otitis media with effusion diagnosed according to strict objective case definitions by age 6 years.

Methods

We evaluated 291 children in the 6th year of life from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) 2000 birth cohort. Otitis media with effusion was diagnosed based on tympanometric and objective evaluation. Asthma, eczema, allergic- and non-allergic rhinitis was diagnosed prospectively by pre-defined algorithms. Nasal mucosal swelling was assessed using acoustic rhinometry and nasal eosinophilia from scrapings.

Analyses were performed using logistic regression and adjusted for dog, cat and smoking exposure, paternal atopy, household income, older siblings, gender and number of acute otitis media episodes.

Results

Otitis media with effusion was diagnosed in 39% of the cohort and was associated with allergic rhinitis (aOR = 3.36, CI = 1.26–8.96, = 0.02), but not with nasal mucosal swelling, nasal oeosinophilia, non-allergic rhinitis, asthma or eczema.

Conclusion

Otitis media with effusion is closely associated with allergic rhinitis presumably caused by allergic inflammation, but not mechanical nasal mucosal swelling. These findings warrant an increased awareness of otitis media with effusion in children with allergic rhinitis.

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