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Clinical & Experimental Allergy

Innate affairs of allergens

Authors

  • W. R. Thomas

    Corresponding author
    • Centre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
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Correspondence:

W. R. Thomas, Telethon Institute for Child Health Research, 100 Roberts Rd, Subiaco 6008, Western Australia. E-mail: wayne@ichr.uwa.edu.au

Summary

Activation of receptors of the innate immune system is a critical step in the initiation of immune responses. It has been shown that dominant allergens have properties that could allow them to interact with toll-like and C-type lectin receptors to favour Th2-biased responses and many bind lipids and glycans that could associate with ligands to mimic pathogen-associated microbial patterns. In accord with the proposed allergen-specific innate interactions it has been shown that the immune responses to different allergens and antigens from the same source are not necessarily coordinately regulated.

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