Hyperpigmentation and hypohidrosis

(THE NAEGELI–FRANCESCHETTI–JADASSOHN SYNDROME): REPORT OF A FAMILY AND REVIEW OF THE LITERATURE

Authors

  • G.P. SPARROW,

    Corresponding author
    1. Department of Dermatology, Guy's Hospital, London sei 9RT, and St John's Hospital for Diseases of the Skin, Lisle Street, London WC2H 7BJ
      Reprint requests: Dr G.P. Sparrow, Department of Dermatology, Guy's Hospital, London, SEI 9RT.
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  • P.D. SAMMAN,

    1. Department of Dermatology, Guy's Hospital, London sei 9RT, and St John's Hospital for Diseases of the Skin, Lisle Street, London WC2H 7BJ
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  • R.S. WELLS

    1. Department of Dermatology, Guy's Hospital, London sei 9RT, and St John's Hospital for Diseases of the Skin, Lisle Street, London WC2H 7BJ
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Reprint requests: Dr G.P. Sparrow, Department of Dermatology, Guy's Hospital, London, SEI 9RT.

Summary

Seven individuals from one family are recorded who have a syndrome consisting of hyperpigmentation, hypohidrosis and dystrophy of the nails. Associated features are punctate keratoses of the palms and soles, hypoplasia of the dermatoglyphics, atrophic changes of the skin of the face, bullae on the feet and dental anomalies. The disorder is inherited as an autosomal dominant trait. The relationship between this and other syndromes with hyperpigmentation is discussed.

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