Investigation of the pharmacokinetics of clobetasol propionate and clobetasone butyrate after a single application of ointment
Article first published online: 27 APR 2006
Clinical and Experimental Dermatology
Volume 8, Issue 2, pages 143–151, March 1983
How to Cite
HEHIR, M., VIVIER, A. D., EILON, L., DANIE, M. J. and SHENOY, E.V.B. (1983), Investigation of the pharmacokinetics of clobetasol propionate and clobetasone butyrate after a single application of ointment. Clinical and Experimental Dermatology, 8: 143–151. doi: 10.1111/j.1365-2230.1983.tb01758.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Accepted for publication 17 February 1982
Using new radioimmunoassay methods, the plasma levels of clobetasol propionate and clobetasone butyrate have been measured following application of ointment to in-patients with psoriasis or eczema.
A single application of 25 g of clobetasol propionate 0·05% ointment caused a rapid rise in plasma clobetasol propionate level during the first 3 h. The level fell gradually but was still appreciable 48 h afterwards. Conversely, the plasma cortisol level fell rapidly after application and remained depressed, not rising to baseline levels until 96 h afterwards.
A single application of 30 g of clobetasone butyrate 0.·05% ointment resulted in a measurable rise in clobetasone butyrate levels during the first 3 h but then the levels fell gradually. The concentrations were approximately ten times lower than those of clobetasol propionate. The normal diurnal variation in plasma cortisol levels was not affected.