Occurrence of lichen planus in a family. Genetic susceptibility or coincidence?


Henning Schmidt, Department of Dermatology, Odense University Hospital, DK-5000 Odense C, Denmark.


A family is presented in which three out of five members suffered from lichen planus. The two children with the disease had inherited the same HLA haplotype from the father, also suffering from lichen planus. A healthy son had the other HLA haplotype from his father. This observation points to a susceptibility gene existing and that this gene may be located in the HLA region.