Photobiology of amiodarone: preliminary in vitro and in vivo studies
Version of Record online: 27 APR 2006
Clinical and Experimental Dermatology
Volume 9, Issue 3, pages 248–255, May 1984
How to Cite
DIFFEY, B.L., CHALMERS, R.J.G. and MUSTON, H.L. (1984), Photobiology of amiodarone: preliminary in vitro and in vivo studies. Clinical and Experimental Dermatology, 9: 248–255. doi: 10.1111/j.1365-2230.1984.tb00791.x
- Issue online: 27 APR 2006
- Version of Record online: 27 APR 2006
- Accepted for publication 8 July 1983
Five patients with photosensitivity due to the cardiac anti-arrhythmic agent amiodarone were shown to have a reduced erythema threshold to UV-A radiation. Measurement of the in vivo action spectrum showed that photosensitivity was maximal at 350 nm and extended up to 400 nm.
Preliminary in vitro analysis suggests that amiodarone itself is not the photosensitizer but that a metabolite is responsible. The possible nature of this metabolite is discussed.