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Summary

The follow up of a case of the carcinoid syndrome complicated by scleroderma is reported, in which progress of the disease may have been halted by treatment with a combinaton of cyproheeptadine, paracholrophenylalanone and prednisolone. Impairment of cyproheptadine, parachlorophenylalanine and prednisolone. Impairment of tryptophan and 5-hydroxytryptamine (serotonon)metabolism appears central to the development of skin fibrosis in the carcinoid syndrome and may be indicative scleroderma.