Conflict of interest: none declared.
Pseudoscleroderma associated with cancer
Article first published online: 14 MAR 2006
Clinical and Experimental Dermatology
Volume 31, Issue 3, pages 381–383, May 2006
How to Cite
Kikuchi, K., Hoashi, T., Yazawa, N. and Tamaki, K. (2006), Pseudoscleroderma associated with cancer. Clinical and Experimental Dermatology, 31: 381–383. doi: 10.1111/j.1365-2230.2006.02092.x
- Issue published online: 14 MAR 2006
- Article first published online: 14 MAR 2006
- Accepted for publication 7 December 2005
In the period 1994–2002, we saw 71 patients with sclerotic skin changes; 66 were diagnosed with systemic sclerosis (SSc) while five (7%) were diagnosed with pseudoscleroderma associated with various malignancies. The mean duration of disease in these five patients was significantly shorter than that of patients with SSc. The incidence of positive antinuclear antibodies, Raynaud's phenomenon or oesophageal involvement in patients with pseudoscleroderma was significantly lower than that in patients with SSc. The distributions of skin sclerosis varied in each case. Serum basic fibroblast growth factor (bFGF) levels in the five patients with pseudoscleroderma were very elevated compared with levels in controls. Elevated expression of bFGF was detected on fibroblasts of affected skin and in one lung-cancer tissue sample obtained by excision.