Conflict of interest: none declared.
Epidermodysplasia verruciformis and generalized verrucosis: the same disease?
Article first published online: 16 MAR 2006
Clinical and Experimental Dermatology
Volume 31, Issue 3, pages 390–393, May 2006
How to Cite
Yanagi, T., Shibaki, A., Tsuji-Abe, Y., Yokota, K. and Shimizu, H. (2006), Epidermodysplasia verruciformis and generalized verrucosis: the same disease?. Clinical and Experimental Dermatology, 31: 390–393. doi: 10.1111/j.1365-2230.2006.02100.x
- Issue published online: 16 MAR 2006
- Article first published online: 16 MAR 2006
- Accepted for publication 21 December 2005
We report a patient with epidermodysplasia verruciformis (EV) who had severe generalized verrucous skin lesions for 50 years without any immunological abnormality. Microscopic examination showed two histopathological features, including seborrhoeic keratosis and common warts. The detected human papilloma virus (HPV) types were found to be HPV 3, 50, 5, and 76, using a degenerate PCR method. EV and generalized verrucosis are distinguished by slight differences in clinical symptoms or HPV types, so there should be no apparent differential points common to both diseases. Therefore, we propose that an abnormal susceptibility specific to HPV, which is the most characteristic feature in EV, should be regarded as a differential point in these two diseases.