Conflict of interest: none declared.
Does the plasma level of vitamins A and E affect acne condition?
Article first published online: 16 MAR 2006
Clinical and Experimental Dermatology
Volume 31, Issue 3, pages 430–434, May 2006
How to Cite
El-akawi, Z., Abdel-Latif, N. and Abdul-Razzak, K. (2006), Does the plasma level of vitamins A and E affect acne condition?. Clinical and Experimental Dermatology, 31: 430–434. doi: 10.1111/j.1365-2230.2006.02106.x
- Issue published online: 16 MAR 2006
- Article first published online: 16 MAR 2006
- Accepted for publication 21 December 2005
Background. Vitamin A and E are lipid soluble antioxidants that are necessary for our health. Deficiency in these vitamins can cause serious diseases. Administration of vitamin A and E to patients with acne was shown to improve their acne condition.
Aims. To test the relationship between plasma vitamin A and E levels and acne.
Methods. Plasma vitamin A and E concentrations were determined by high performance liquid chromatography in 100 newly diagnosed untreated patients with acne and were compared with those of 100 age-matched healthy controls. Patients were carefully graded using the Global Acne Grading System.
Results. We found that plasma vitamin A concentrations in patients with acne were significantly lower than those of the control group (336.5 vs. 418.1 μg/L, respectively) P = 0.007. We also found that plasma vitamin E concentrations in patients with acne were significantly lower than those of controls (5.4 vs. 5.9 mg/L) P = 0.05. In addition, we found that there is a strong relationship between decrease in plasma vitamin A levels and increase in the severity of acne condition. Patients with severe acne had significantly lower plasma concentrations of vitamins A and E than did those with lower acne grade and the age-matched healthy controls.
Discussion. Based on our results, we conclude that low vitamin A and E plasma levels have an important role in the pathogenesis of acne and in the aggravation of this condition.