Conflict of interest: none declared.
Glomeruloid haemangioma is not always associated with POEMS syndrome
Article first published online: 9 DEC 2008
© 2008 The Author(s). Journal compilation © 2008 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 34, Issue 7, pages 800–803, October 2009
How to Cite
González-Guerra, E., Haro, M. R., Fariña, M. C., Martín, L., Manzarbeitia, L. and Requena, L. (2009), Glomeruloid haemangioma is not always associated with POEMS syndrome. Clinical and Experimental Dermatology, 34: 800–803. doi: 10.1111/j.1365-2230.2008.02997.x
- Issue published online: 2 SEP 2009
- Article first published online: 9 DEC 2008
- Accepted for publication 6 June 2008
Glomeruloid haemangioma is considered a specific marker of POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome and it is usually but not always associated with multicentric Castleman’s disease. We report a 78-year-old man who presented with a single, red-violet soft nodule with superficial telangiectases on the scalp. Histopathologically, the lesion consisted of lobules of coiled aggregated capillaries that involved the lumina of dilated vascular structures, mimicking renal glomeruli. A collagenous stroma separated the capillary lobules, and eosinophilic, periodic-acid–Schiff positive globules of varying sizes and shapes were seen within the cytoplasm of endothelial cells. Immunohistochemical studies with antibodies against IgA and IgG, and against the kappa and lambda light chains of immunoglobulins showed immunoreactivity within the eosinophilic globules. Results of complete blood count, liver, renal and thyroid function tests, fasting blood sugar measurement, serum levels of oestradiol, testosterone, prolactin and cortisol, serum protein electrophoresis, immunoelectrophoresis and immunofixation yielded normal or negative results. No Bence–Jones proteinuria was found in a sample from a 24-h urine collection. To our knowledge, only two cases of glomeruloid haemangioma have been previously reported in patients without POEMS syndrome. We describe the third case of glomeruloid haemangioma in a patient without features of POEMS syndrome.