Conflict of interest: none declared.
Sebaceous gland hyperplasia of the foreskin
Article first published online: 9 DEC 2008
© 2008 The Author(s). Journal compilation © 2008 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 34, Issue 3, pages 372–374, April 2009
How to Cite
Ena, P., Origa, D. and Massarelli, G. (2009), Sebaceous gland hyperplasia of the foreskin. Clinical and Experimental Dermatology, 34: 372–374. doi: 10.1111/j.1365-2230.2008.02998.x
- Issue published online: 12 MAR 2009
- Article first published online: 9 DEC 2008
- Accepted for publication 13 January 2008
Two men, aged in their 20s, presented with multiple, soft, rounded papules on the prepuce. The lesions were centrally umbilicated, resembling molluscum contagiosum, but clearly distinct from Tyson’s glands. Surface microscopy showed well-defined, milky-white, bag-shaped structures, which under histological examination were found to be sebaceous glands with various features of hyperplasia. A lymphocytic T-cell infiltrate, closely associated with progressive degeneration and destruction of the sebocytes, was visible around the glands. In the differential diagnosis of penile papular lesions, this unusual clinical presentation supported by dermatoscopy is consistent with preputial sebaceous gland hyperplasia. As both patients had a prominent T-cell infiltration, it is possible that under inflammatory stimulation, sebaceous glands undergo hypertrophy and gradual central involution.