Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking


  • Conflict of interest: none declared.

Dr Sarah A. Walsh, Department of Dermatology, Normanby Building, King’s College Hospital, Denmark Hill, London, SE5 9RS, UK
E-mail: sarahwalsh1@nhs.net


Summary Drug reaction with eosinophilia and systemic symptoms (DRESS) describes a severe medication-induced adverse reaction, which has cutaneous, haematological and solid-organ features. It is one of the triad of life-threatening drug hypersensitivity dermatoses, along with acute generalized exanthematous pustulosis (AGEP) and Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). In this article, we discuss several controversies that surround DRESS, including problems with nomenclature and the lack of consensus in diagnostic criteria.