Conflict of interest: none declared.
Experimental dermatology •Original article
Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum
Article first published online: 25 AUG 2011
© The Author(s). CED © 2011 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 36, Issue 8, pages 903–907, December 2011
How to Cite
Yamasaki, O., Morizane, S., Aochi, S., Ogawa, K., Oono, T. and Iwatsuki, K. (2011), Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum. Clinical and Experimental Dermatology, 36: 903–907. doi: 10.1111/j.1365-2230.2011.04159.x
- Issue published online: 10 NOV 2011
- Article first published online: 25 AUG 2011
- Accepted for publication 2 May 2011
Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells.
Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD.
Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA.
Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD.
Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.