Conflict of interest: none declared.
Clinical dermatology •Concise report
Vulval and perianal intraepithelial neoplasia: response to chemoradiotherapy in a woman with idiopathic CD4 lymphocytopenia
Article first published online: 22 MAR 2012
© The Author(s). CED © 2012 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 37, Issue 8, pages 865–868, December 2012
How to Cite
Tomson, N., Sterling, J., Miller, R., Wilson, C. and Baldwin, P. (2012), Vulval and perianal intraepithelial neoplasia: response to chemoradiotherapy in a woman with idiopathic CD4 lymphocytopenia. Clinical and Experimental Dermatology, 37: 865–868. doi: 10.1111/j.1365-2230.2012.04342.x
- Issue published online: 21 NOV 2012
- Article first published online: 22 MAR 2012
- Accepted for publication 2 December 2011
Treatment of multicentric or multifocal anogenital intraepithelial neoplasia is challenging, especially if the patient has immunodeficiency. We report the case of a woman with idiopathic CD4 lymphocytopenia and vulval and perianal intraepithelial neoplasia with early invasive disease, who responded well to radiotherapy combined with chemotherapy. Chemoradiotherapy is often used in the primary treatment of anal carcinomas, but has rarely been reported as a treatment for premalignant anogenital conditions.