Conflict of interest: none declared.
Clinical dermatology •Concise report
Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate
Article first published online: 30 APR 2012
© The Author(s). CED © 2012 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 37, Issue 8, pages 874–878, December 2012
How to Cite
Smith, V. M., Oliphant, T., Shareef, M., Merchant, W. and Wilkinson, S. M. (2012), Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate. Clinical and Experimental Dermatology, 37: 874–878. doi: 10.1111/j.1365-2230.2012.04350.x
- Issue published online: 21 NOV 2012
- Article first published online: 30 APR 2012
- Accepted for publication 20 December 2011
Calciphylaxis is a rare and potentially life-threatening condition. It is thought to result from arterial calcification causing complete vascular occlusion and subsequent cutaneous infarction. Most often, it is a complication of end-stage renal failure or hyperparathyroidism; without either of these associated conditions, it is extremely rare. We report a case of calciphylaxis in a 58-year-old white British man, who had received long-term oral prednisolone for asthma control, with prophylactic calcium supplementation. There was no history of renal failure, and the patient’s parathyroid function was normal. He was found to be heterozygous for the Factor V Leiden mutation. The acute presentation was seemingly precipitated by an episode of trauma and subsequent compression bandaging. The patient responded promptly to intravenous sodium thiosulfate. To our knowledge, this is the first case with no history of renal failure and normal parathyroid function, precipitated by compression bandaging and with an associated Factor V Leiden mutation.