This case was previously presented as a poster at the December 2009 New England Dermatologic Society Meeting, Boston, MA, USA and at the 2010 Annual Meeting of the American Society of Dermatologic Surgery, Chicago, IL, USA.
Clinical dermatology •Concise report
Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy
Article first published online: 30 APR 2012
© The Author(s). CED © 2012 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 37, Issue 7, pages 759–761, October 2012
How to Cite
Mendese, G. W., Beckford, A., Krejci, N., Mahalingam, M., Goldberg, L. and Gilchrest, B. A. (2012), Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy. Clinical and Experimental Dermatology, 37: 759–761. doi: 10.1111/j.1365-2230.2012.04352.x
Conflict of interest: none declared.
- Issue published online: 24 SEP 2012
- Article first published online: 30 APR 2012
- Accepted for publication 28 December 2011
Pagetoid reticulosis or Woringer–Kolopp disease (WKD) is a rare variant of mycosis fungoides, consisting of localized patches or plaques containing intraepidermal proliferations of neoplastic T cells in a pagetoid distribution (similar to that of the adenocarcinomatous cells found in Paget disease of the nipple), which typically affects middle-aged and elderly men. We report a trial of photodynamic therapy (PDT) with topical aminolaevulinic acid (ALA), carried out on a 10-year-old boy with a solitary lesion of WKD on his foot, to avoid the long-term problems associated with the typical treatments for WKD of surgery and/or local irradiation. The plaque progressively flattened during treatment, and after nine PDT sessions over 13 months, the patient was clinically free of disease. PDT may be a viable alternative to surgery and local irradiation for localized cutaneous T-cell lymphoma, including WKD, especially in younger patients.