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Glutathione S-transferase M1 and T1 genetic polymorphism in Egyptian patients with nonsegmental vitiligo

Authors


  • Conflict of interest: none declared.

Dr Dalia Ahmed Bassiouny, Department of Dermatology, Faculty of Medicine, Kasr El-Ainy University Hospital, Cairo University, 51B Damascus Street, Mohandessien, 12411 Cairo, Egypt
E-mail: daliabas73@yahoo.com

Summary

Oxidative stress and accumulation of free radicals might play a role in the pathogenesis of vitiligo. Glutathione S-transferase (GST) is a multigene family of enzymes that detoxify oxidative stress products. In this study, genotyping by multiplex PCR of GSTM1 and GSTT1 in 101 women with nonsegmental vitiligo vulgaris and 101 age-matched healthy female volunteers showed that only the GSTM1 null genotype (= 0.04) was significantly overexpressed in patients with vitiligo. Analysis of the combined effect of GSTM1 and GSTT1 genotyping identified a significant association of risk for vitiligo with the GSTT1/GSTM1 double-null type only (= 0.01; OR = 2.69; 95% CI 1.12–6.46). Age of onset of vitiligo was significantly earlier in patients with the T1 null genotype (< 0.01) and those with the T1−/M1+ and T1−/M1− combined genotypes (< 0.01 and = 0.01, respectively). In conclusion, the GSTM1 gene and the GSTM1/GSTT1 double-null genotype may be a risk factor for vitiligo in Egyptian patients. Inability to cope with oxidative stresses because of GST deficiency may cause early disease onset.

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