Conflict of interest: none declared.
Clinical dermatology •Review article
Clear cell acanthoma
Article first published online: 21 NOV 2012
© The Author(s). CED © 2012 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 37, Issue 8, pages 831–837, December 2012
How to Cite
Tempark, T. and Shwayder, T. (2012), Clear cell acanthoma. Clinical and Experimental Dermatology, 37: 831–837. doi: 10.1111/j.1365-2230.2012.04428.x
- Issue published online: 21 NOV 2012
- Article first published online: 21 NOV 2012
- Accepted for publication 28 February 2012
Clear cell acanthoma (CCA), is an asymptomatic benign lesion of unknown origin and aetiology, which typically presents as a red to brown, dome-shaped papule on the leg. We discuss the case of a patient with an irregular plaque of hypopigmented papules whose diagnosis of CCA was only made by biopsy, and review the characteristic presentation, uncommon variants, locations and associated conditions of this lesion. The diagnosis is based on histopathology and/or immunohistochemistry, but the variable clinical presentation may make diagnosis difficult. The differential diagnosis includes skin tumours and inflammatory and pigmentary dermatoses. The lesions do not regress spontaneously, and excisional removal is the preferred treatment.