Idiopathic pure sudomotor failure and cholinergic urticaria in a patient after acute infectious mononucleosis infection

Authors

  • Y.-Y. Chin,

    1. Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    2. Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    3. Department of Dermatology, Kaohsiung Municiple Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
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  • T. C.-C. Chang,

    1. Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    2. Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
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  • C.-H. Chang

    1. Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    2. Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
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  • Conflict of interest: none.

Prof. Chung-Hsing Chang, Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan and Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Postal address: No. 100, Tzyou 1st Road Kaohsiung 807, Taiwan, R.O.C.
E-mail: 970457@mail.kmuh.org.tw

Summary

Idiopathic pure sudomotor failure (IPSF) is a subgroup of acquired idiopathic generalized anhidrosis, which is characterized by early age of onset, acute or sudden onset, concomitant sharp pain or cholinergic urticaria over the entire body, absence of autonomic dysfunction other than generalized anhidrosis, raised serum IgE level, and marked response to steroid. The aetiology of IPSF is still not well understood, but is thought to be caused by interference in cholinergic transmission in the eccrine glands of skin. IPSF after viral infection has rarely been reported in the literature. We describe a patient who developed generalized anhidrosis and cholinergic urticaria accompanied by heat intolerance after infectious mononucleosis infection. This is the first such case, to our knowledge, and the patient was successfully treated with steroid pulse therapy.

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