Conflict of interest: none declared.
Clinical dermatology •Concise report
Facial ulcer treated with olanzapine
Article first published online: 23 APR 2013
© 2013 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 38, Issue 5, pages 504–506, July 2013
How to Cite
Lowry, C. L., Bewley, A. and Taylor, R. (2013), Facial ulcer treated with olanzapine. Clinical and Experimental Dermatology, 38: 504–506. doi: 10.1111/j.1365-2230.2012.04448.x
- Issue published online: 18 JUN 2013
- Article first published online: 23 APR 2013
- Accepted for publication 11 May 2012
A 69-year-old woman presented with a nonhealing ulcer on her right cheek. On histological examination of a biopsy, no evidence of granuloma formation or malignancy was found, and the overall picture was felt to be consistent with dermatitis artefacta (DA). The patient was referred to a joint psychodermatology clinic, where treatment with risperidone was started. However, at follow-up the ulcer remained unchanged, and treatment was changed to olanzapine 2.5 mg twice daily. Within 10 months, the large facial ulcer, which had been refractory to treatment for several years, had completely healed. Anxiolytics, antidepressants and low-dose antipsychotics have been shown to be helpful in the management of DA. Successful treatment with olanzapine has been described. The good clinical response to olanzapine may be attributed to its anti-impulsive effect, antihistaminic properties and low risk of parkinsonian side-effects.