Conflict of interest: none declared.
Clinical dermatology •Original article
Association between multiple cutaneous melanoma and other primary neoplasms
Article first published online: 1 OCT 2012
© The Author(s). CED © 2012 British Association of Dermatologists
Clinical and Experimental Dermatology
Volume 37, Issue 8, pages 857–861, December 2012
How to Cite
Manganoni, A. M., Pavoni, L., Farisoglio, C., Sereni, E., Chiudinelli, M. and Calzavara-Pinton, P. (2012), Association between multiple cutaneous melanoma and other primary neoplasms. Clinical and Experimental Dermatology, 37: 857–861. doi: 10.1111/j.1365-2230.2012.04455.x
- Issue published online: 21 NOV 2012
- Article first published online: 1 OCT 2012
- Accepted for publication 2 May 2012
Background. The risk of a subsequent cancer is an important issue for patients with melanoma. The development of a second primary cancer in patients with a solitary melanoma has been discussed in several studies. However, to our knowledge, the incidence of second primary cancer (SPC) in patients with multiple primary melanoma (MPM) has not been thoroughly investigated.
Aim. To quantify the incidence of SPC in patients with MPM, with the aim of possibly developing further preventive measures.
Methods. In a retrospective study, 76 patients with MPM were identified from 2155 patients being followed up at our unit.
Results. Of the 76 patients, 12 (16%) developed another neoplasm, with 59% of them having nonmelanoma skin cancer (NMSC), and 41% other noncutaneous cancers. By contrast, only 8% of those with single primary melanoma had other neoplasms (21% of whom had NMSC).
Conclusions. Patients with MPM, especially men with skin phototype II, have a significantly increased incidence of developing SPC, particularly NMSC. Thus, careful monitoring is essential not only to detect recurrence of the original cancer or development of another primary melanoma, but also development of new malignancies of different types, particularly NMSC.