• Barnaba, V., Franco, A., Alberti, A., Balsano, C., Benvenuto, R. & Balsano, F. (1989) Recognition of hepatitis B virus envelope proteins by liver-infiltrating T lymphocytes in chronic HBV infection. J. Immunol. 143, 2650.
  • Böyum, A. (1968) Separation of leucocytes from blood and bone marrow. Stand. J. clin. Lab. Invest. 21, 1.
  • Eggink, H.-F., Houthoff, H.J., Huhema, S., Gips, C.H. & Poppema, S. (1982) Cellular and humoral immune reactions in chronic active liver disease. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis. Clin. exp. Immunol. 50, 17.
  • Fleischer, B. & Kreth, H.W. (1983) Clonal analysis of HLA-restricted vims specific T lymphocytes from cerebrospinal fluid in mumps meningitis. J. Immunol. 130, 2187.
  • Fleischer, B. & Wagner, H. (1986) Significance of T4 or T8 phenotype of human cytotoxic T-lymphocyte clones. Curr. Top. Microbiol. Immunol. 126, 101.
  • Gonzalez, F.J., Skoda, R.C., Kimura, S., Umeno, M., Zanger, U.M., Nebert, D.W., Gelboin, H.V., Hardwick, I. & Meyer, U.A. (1988) Characterisation of the common genetic defect in humans deficient in debrisoquine metabolism. Nature, 331, 442.
  • Holzmann, B. & Johnson, J. (1983) A β-gaIactosidase-linked immunoassay for the analysis of antigens on individual cells. J. immunol. Methods, 60, 359.
  • Homberg, J.-C., Abraf, N., Bernard, O., Islam, S., Alvarez, F., Khalil, S.H., Poupon, R., Darmis, F., Levy, V., Grippon, P., Opolon, P., Bernuar, J., Benhamou, J. & Alagille, D. (1987) Chronic active hepatitis associated with anti liver/kidney microsome antibody type I: a second type of “autoimmune hepatitis”. Hepatology, 7, 1333.
  • Lobo-Yeo, A., Alviggi, L., Mieli-Vergani, G., Portmann, B., Mowat, A. & Vergani, D. (1987) Preferential activation of helper/ inducer T lymphocytes in autoimmune chronic active hepatitis. Clin. exp. Immunol. 67, 95.
  • Löhr, H., Treichel, U., Poralla, T., Manns, M., Meyer Zum Büschenfelde, K.-H. & Fleischer, B. (1990) The human asialoglycoprotein receptor is a target antigen for liver-infiltrating T cells in autoimmune chronic active hepatitis and primary biliary cirrhosis. Hepatology, 12, 314.
  • Long, E.O. (1989) Intracellular traffic and antigen processing. Immunol. Today. 10, 232.
  • Maghoub, A., Idle, J.R., Dring, L.G., Lancaster, R. & Smith, R.L. (1977) Polymorphic hydroxylation of debrisoquine in man. Lancet, ii, 584.
  • Manns, M. (1989) Autoantibodies and antigens in liver diseases—updated. Hepatology. 9, 272.
  • Manns, M., Johnson, E.F., Griffin, K.J., Tan, EM., Sullivan, K.F. (1989) Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450dbl. J. Clin. Invest. 83, 1066.
  • Manns, M., Meyer Zum Büschenfelde, K.-H., Slusarczyk, J. & Dienes, H.P. (1984) Detection of liver-kidney microsomal antibodies by radioimmunoassay and their relation to antimitochondrial antibodies in inflammatory liver diseases. Clin. exp. Immunol. 57, 600.
  • Meuer, S.C., Manns, M., Dienes, H.P., Ramadori, G., Hess, G., Hütteroth, T.H., Hercend, T. & Meyer Zum Büschenfelde, K.-H. (1988) Clonal analysis of human T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis. Eur. J. Immunol. 18, 1447.
  • Pape, G.R., Rieber, E.P., Eisenburg, J., Hoffman, R., Balch, C.M., Paumgartner, G. & Riethmüller, G. (1983) Involvement of the cytotoxic/suppressor T-cell subset in liver tissue injury of patients with acute and chronic liver diseases. Gastroenterology, 85, 657.
  • Rizzetto, M., Swana, G. & Doniach, D. (1973) Microsomal antibodies in active chrome hepatitis and other disorders. Clin. exp. Immunol. 15, 331.
  • Townsend, A.R., Rothbard, J., Gotch, F.M., Bahadur, G., Wraith, D. & McMichael, A.J. (1986) The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell. 44, 959.
  • Vallbracht, A., Maier, K., Stierhof, Y., Wiedmann, K.H., Flehmig, B. & Fleischer, B. (1989) Liver-derived cytotoxic T cells in hepatitis A virus infection. J. infect. Dis. 160, 209.
  • van der Pouw Kraan, T., Stiekema, F.E., Teunissen, M.B., Bos, J.D. & Kapsenberg, L. (1989) The selective antigen-presenting cell capacity of activated B lymphocytes in HLA-II-restricted responses of CD4+ T lymphocytes. Immunology, 68, 147.
  • Vento, S. & Eddleston, A.L. (1987) Immunological aspects of chronic active hepatitis. Clin. exp. Immunol. 68, 225.
  • Zanger, U.M., Hauri, H.P., Loeper, J., Homberg, J.-C. & Meyer, U.A. (1988) Antibodies against human cytochrome P450 dbl in autoimmune hepatitis type II. Proc. natl Acad. Sci. USA, 27, 8256.