• 1
    Primary immunodeficiency diseases: report of a WHO scientific group. Immunodef Rev 1992; 3:195236.
  • 2
    Webster ADB, Asherson GL. Identification and function of T cells in the peripheral blood of patients with hypogammaglobulinaemia. Clin Exp Immunol 1974; 18:499504.
  • 3
    Spickett GP, Webster ADB, Farrant J. Cellular abnormalities in common variable immunodeficiency. Immunodef Rev 1990; 2:199219.
  • 4
    Spickett GP, Matamoros N, Farrant J. Lymphocyte surface phenotype in common variable immunodeficiency. Dis Markers 1992; 10:6780.
  • 5
    Saxon A, Macy E, Denis K, Tary- Lehmann M, Witte O, Braun J. Limited B cell repertoire in severe combined immunodeficient mice engrailed with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J Clin invest 1991; 87:65865.
  • 6
    Smith CIE, Abedi MR, Islam KB, Johansson MEB, Christensson B, Hammarstrom L. Humoral immunity in scid mice reconstituted with cells from immunoglobulin-deficient or normal humans, Immunol Rev 1991; 124:11338.
  • 7
    Simpson E, Farrant J, Chandler P. Phenotypic and functional studies of human peripheral blood lymphocytes engrafted in SCID mice. Immunol Rev 1991; 124:97111.
  • 8
    Bryant A, Calver NC, Toubi E, Webster ADB, Farrant J. Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin Immunol Immunopathol 1990: 56:23948.
  • 9
    North ME, Spickett GP, Allsop J, Webster ADB, Farrant J. Defective DNA synthesis by T cells in acquired “common-variable” hypogammaglobulinaemia on stimulation with mitogens. Clin Exp Immunol 1989; 76:1923.
  • 10
    North ME, Webster ADB, Farrant J. Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C. Clin Exp Immunol 1991; 85:198201.
  • 11
    Eibl MM, Mannhalter JW, Zlabinger G, Mayr WR, Tilz GP, Ahmad R, Ziclinski CC. Defective macrophage function in a patient with common variable immunodeficiency. New Engl J Med 1982: 307:8036.
  • 12
    Eibl MM, Mannhalter JW, Zielinski CC, Ahmad R. Defective macrophage-T-cell interaction in common varied immunodeficiency. Clin Immunol Immunopathol 1982; 22:31622.
  • 13
    Mannhulter JW, Ahmad R, Eibl MM. Deficient antigen presentation in a patient with common variable immunodeficiency. Immunologia Polska 1986; 11:17383.
  • 14
    Farrant J, Bryant AE, Lever AML, Edwards AJ, Knight SC, Webster ADB. Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia; low immunoglobulin production on stimulation of normal B cells. Clin Exp Immunol 1985; 61:18994.
  • 15
    Macatonia SE, Taylor PM, Knight SC, Askonas BA. Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J Exp Med 1989; 169:125564.
  • 16
    Macatonia SE, Patterson S, Knight SC. Primary proliferative and cytotoxic T-cell responses to HIV induced in vitro by human dendritic cells. Immunology 1991; 74:399406.
  • 17
    Knight SC, Farrant J, Bryant A et at. Non-adherent, low density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 1986; 59:595603.
  • 18
    Stagg AJ, Harding B, Hughes RA, Keat A, Knight SC. The distribution and functional properties of dendritic cells in patients with seronegative arthritis, Clin Exp Immunol 1991; 84:6671.
  • 19
    Poulter LW, Campbell DA, Munro C, Janossy G. Discrimination of human macrophages and dendritic ceils by means of monoclonal antibodies, Scand J Immunol 1986: 24:3517.
  • 20
    Saxon A, Feldhaus J, Robins RA. Single step separation of human T and B cells using AET treated SRBC rosettes, J Immunol Methods 1976; 12:2858.
  • 21
    Farrant J, Clark JC, Lee H, Knight SC, O'Brien J. Conditions for measuring DNA synthesis in PHA stimulated human lymphocytes in 20 μl hanging drops with various ceil concentrations and periods of culture, J Immunol Methods 1980; 33:30112.
  • 22
    Knight SC. Lymphocyte proliferation assays. In: KlausGGB. ed. Lymphocytes—a practical approach. Oxford : IRL Press. 1988; i:89207.
  • 23
    Knight SC, Harding B, Burman S, Merton J. Cell number requirements for lymphocyte stimulation IN vitro: changes during the course of multiple sclerosis and the effects of immunosuppression. Clin Exp Immunol 1981; 46:619.
  • 24
    Macatonia SE, Gompels M, Pinching AJ, Patterson S, Knight SC. Antigen presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection. Immunology 1992; 75:57681.
  • 25
    Sa'adu A, Thomson BJ, Bountiff L, Webster ADB. Lymphotropic viruses in “common variable” immunodeficiency—PCR analysis of lymphocyte DNA for HIV-I and HHV-6. Clin Exp Immunol 1993: 91:503.
  • 26
    Gray D, Kosco M, Stockinger B. Novel pathways of antigen presentation for the maintenance of memory, internal Immunol 1991: 3:1418.
  • 27
    Splawski JB, Fu SM, Lipsky PE. Immunoregulatory role of CD40 in human B cell differentiation. J Immunol 1993; 150:127685.
  • 28
    Krugor G, Welte K, Ciobanu N et al. Interlcukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency. J Clin Immunol 1984; 4:295303.
  • 29
    Fiedler W, Sykora KW, Welte K et al. T-cell activation defect in common variable immunodeficiency: restoration by phorbol myristate acetate (PMA) or allogeneic macrophages, Clin Immunol Immunopathol 1987; 44:20618.
  • 30
    Sneller MC, Strober W. Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency. J Immunol 1990: 144; 37629.