• 1
    Abba IT. Mechanisms of hypersensitivity. In: DanilelPS, AbbaIT, Eds. Basic and clinical immunology. East Norwark , Appleton & Lange. 1991:36799.
  • 2
    Miyamoto T, Johansson SGO, Itoh K et al. Atopic allergy in Japanese subjects: studies primarily with radioallergosorbent test. J Allergy Clin Immunol 1974; 53:919.
  • 3
    del Prete G, Maggi E, Parronchi P et al. IL-4 is an essential factor for the IgE synthesis induced by human T cell clones and their supernatants. J Immunol 1988; 140:41938.
  • 4
    Pène J, Rousset F, Briere F et al. IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-γ. J Immunol 1988; 141:121824.
  • 5
    Vercelli D, Jabara HH, Arai K et al. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC antigens. J Exp Med 1989; 169:1295307.
  • 6
    Rousset F, Garcia E, Defrance T et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992; 89:18903.
  • 7
    Aamitage RJ, Macduff BM, Springs MK et al. Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J Immunol 1993; 150:367180.
  • 8
    Pène J, Rousset F, Briere F et al. IgE production by normal human lymphocytes is induced by IL-4 and suppressed by interferons-γ,-α and prostaglandin E-2. Proc Natl Acad Sci USA 1988; 85:68804.
  • 9
    Wierenga EA, Snoek M, de Groot C et al. Evidence for compartmentalization of functional subsets of CD4* T lymphocytes in atopic patients. J Immunol 1990; 144:46516.
  • 10
    Parronchi P, Macchia D, Piccinni M-P et al. Allergen- and bacterial antigen-specific T-cell clones established from atopic donor s show a different profile of cytokine production. Proc Natl Acad Sci USA 1991; 88:453842.
  • 11
    O'Hehir RE, Bal V, Quint D et al. An in vitro model of allergen-dependent IgE synthesis by human B lymphocytes: comparison of the response of atopic and a non-atopic individual to Dermatophagoides spp. (house dust mite). Immunology 1989; 66:499504.
  • 12
    Abrams JS, Roncarolo M-G, Vessel H et al. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev 1992; 127:524.
  • 13
    Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21:7790.
  • 14
    Chen PP, Nonaka M, O'Hair OC et al. Human IgE synthesis in vitro by pokeweed mitogen-stimulated human lymphoid cells: verification with a reconfirmed ɛ-specific radioimmunoassay. J Immunol 1984; 133:190913.
  • 15
    Pryjma J, Muñoz J, Virella G et al. Evaluation DT IgM, IgG, IgA, IgD and IgE secretion by human peripheral blood lymphocytes in cultures stimulated with pokeweed mitogen and Staphylococcus aureus Cowan I. Cell Immunol 1979; 50:11524.
  • 16
    Saxon A, Stevens RH. Stimulation and regulation of human IgE production in vitro using peripheral blood lymphocytes, din Immunol Immunopathol 1979; 14:47488.
  • 17
    Yang X-D, de Week AL, Stadler BM. Effect of recombinant human interleukin 4 on spontaneous in vitro human IgE synthesis. Eur J Immunol 1988; 18:1699704.
  • 18
    Jelinek DF, Lipsky PE. Inhibitory influence of IL-4 on human B cell responsiveness. J Immunol 1988; 141:16473.
  • 19
    Llorente L, Crevon M-C. Interleukin (IL)4 counteracts the helper effect of IL2 on antigen-activated human B cells. J Immunol 1989; 19:7659.
  • 20
    Kotowicz K, Callard RE. Human immunoglobulin class and IgG subclass regulation: dual action of interleukin-4. Eur J Immunol 1993; 23:22506.
  • 21
    Defrance T, Vanbervliet B, Brière F et al. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med 1992; 175:67182.
  • 22
    Fluckiger A-C, Garrone P, Durand I et al. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J Exp Med 1993; 178:147381.
  • 23
    Punnonen J, de Waal Malefyt R, van Vlasselaser P et al. IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes. J Immunol 1993; 151: 12809.
  • 24
    de Waal Malefyt R, Abrams J, Bennett B et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an auto-regulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:120920.
  • 25
    Aversa G, Punnonen J, Cocks BG et al. An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation; support for a common component shared by IL-4 and IL-13 receptors. J Exp Med 1993; 178:22138.
  • 26
    Cocks B, de Waal Malefyt R, Galizzi J-P et al. IL-13 induces proliferation and differentiation of human B cells activated by CD40 ligand. Int Immunol 1993; 5:65763.
  • 27
    Punnoncn J, Aversa G, Cocks BG et al. Interleukin 13 induces Interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993; 90:37304.
  • 28
    Kiniwa M, Gately M, Gubler U et al. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J Clin Invest 1992; 90:2626.
  • 29
    Manetti R, Parronchi P, Guidizi G et al. Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper type 1 (Th 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993; 177:1199204.
  • 30
    Chan SH, Perussia B, Gupta JW et al. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 1993; 173:86979.
  • 31
    Spielberg HL, Falkoff RJM, O'Conner RD et al. Interleukin-2 inhibits the interlcukin-4-induced human IgE and IgG4 secretion in vitro. Clin Exp Immunol 1991; 84:4005.