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Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7– effector-memory T cells†
Article first published online: 20 OCT 2004
Clinical & Experimental Immunology
Volume 138, Issue 2, pages 278–289, November 2004
How to Cite
HOLM, A. M., SIVERTSEN, E. A., TUNHEIM, S. H., HAUG, T., BJERKELI, V., YNDESTAD, A., AUKRUST, P. and FRØLAND, S. S. (2004), Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7– effector-memory T cells. Clinical & Experimental Immunology, 138: 278–289. doi: 10.1111/j.1365-2249.2004.02630.x
- Issue published online: 20 OCT 2004
- Article first published online: 20 OCT 2004
- ( Accepted for publication 25 August 2004)
- T cell
Common variable immunodeficiency (CVID) represents a heterogeneous group of antibody deficiency syndromes, characterized by defective antibody production in which T cell deficiency may play a pathogenic role. A subgroup of CVID patients has impaired in vitro T cell proliferation. Using microarray analyses of T cells from these patients, we found a gene expression pattern different from healthy controls and patients with X-linked agammaglobulinaemia. The profile of the differentially expressed genes suggests enhanced cytotoxic effector functions, antigen experienced or chronically activated T cells and a predominance of CCR7– T cells. Further experiments using flow cytometry revealed a striking predominance of CCR7– T cells in a subgroup of CVID patients, and an association with impaired T cell proliferation. Our observations indicate that a predominance of CCR7– T cells with effector-memory cell features and with reduced proliferative capacity may characterize a subgroup of CVID.