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Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus

  1. S. Elahi1,
  2. G. Pang2,
  3. R. Ashman3,
  4. R. Clancy2

Article first published online: 17 MAY 2005

DOI: 10.1111/j.1365-2249.2005.02811.x

Issue

Clinical & Experimental Immunology

Clinical & Experimental Immunology

Volume 141, Issue 1, pages 29–36, July 2005

Additional Information

How to Cite

Elahi, S., Pang, G., Ashman, R. and Clancy, R. (2005), Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus. Clinical & Experimental Immunology, 141: 29–36. doi: 10.1111/j.1365-2249.2005.02811.x

Author Information

  1. 1

    Vaccine and Infectious Disease Organization, University of Sasketchewan, Sasketoon, Canada,

  2. 2

    Discipline of Immunology and Microbiology, Faculty of Health, University of Newcastle, NSW, Australia, and

  3. 3

    School of Dentistry, University of Queensland, Brisbane, Queensland, Australia

*Professor Robert Clancy, Discipline of Immunology and Microbiology, Faculty of Health, David Maddison Clinical Science Building, Royal Newcastle Hospital, Newcastle, NSW 2300, Australia. E-mail: robert.clancy@newcastle.edu.au

Publication History

  1. Issue published online: 15 JUN 2005
  2. Article first published online: 17 MAY 2005
  3. Accepted for publication 10 March 2005

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Keywords:

  • C. albicans;
  • cytokine;
  • lactobacilli;
  • nitric oxide

Summary

Orally administered live Lactobacillus acidophilus was assessed for its capacity to enhance clearance from the oral cavity of DBA/2 mice shown previously to be ‘infection prone’. L. acidophilus fed to DBA/2 mice significantly shortened the duration of colonization of the oral cavity compared to controls. Enhanced clearance of Candida albicans correlated with both early mRNA gene expression for interleukin (IL)-4 and interferon (IFN)-γ and expression of their secreted products in cultures of cervical lymph nodes stimulated with Candida antigen. In addition rapid clearance correlated with higher levels of IFN-γ and nitric oxide in saliva. Delayed clearance, less pronounced levels of the cytokine response, saliva IFN-γ and nitric oxide, and later mRNA expression for IL-4 and IFN-γ relative to feeding with the L. acidophilus isolate were noted in mice fed a different Lactobacillus isolate (L. fermentum). These observations indicate significant variations in individual isolates to activate the common mucosal system.

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