The role of microorganisms in atopic dermatitis
Version of Record online: 16 FEB 2006
Clinical & Experimental Immunology
Volume 144, Issue 1, pages 1–9, April 2006
How to Cite
Baker, B. S. (2006), The role of microorganisms in atopic dermatitis. Clinical & Experimental Immunology, 144: 1–9. doi: 10.1111/j.1365-2249.2005.02980.x
- Issue online: 16 FEB 2006
- Version of Record online: 16 FEB 2006
- Accepted for publication 14 October 2005
Atopic dermatitis (AD) is a common, fluctuating skin disease that is often associated with atopic conditions such as asthma and IgE-mediated food allergy and whose skin lesions are characterized by a Th-2 cell-mediated response to environmental antigens. The increasing prevalence and severity of atopic diseases including AD over the last three decades has been attributed to decreased exposure to microorganisms during early life, which may result in an altered Th-1/Th-2-balance and/or reduced T cell regulation of the immune response. Patients with AD exhibit defects in innate and acquired immune responses resulting in a heightened susceptibility to bacterial, fungal and viral infections, most notably colonization by S. aureus. Toxins produced by S. aureus exacerbate disease activity by both the induction of toxin-specific IgE and the activation of various cell types including Th-2 cells, eosinophils and keratinocytes. Allergens expressed by the yeast Malazessia furfur, a component of normal skin flora, have also been implicated in disease pathogenesis in a subset of AD patients.
Microorganisms play an influential role in AD pathogenesis, interacting with disease susceptibility genes to cause initiation and/or exacerbation of disease activity.