• 1
    Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies. Clin Immunol 1999; 93: 1907.
  • 2
    Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 1999; 92: 3448.
  • 3
    Mellemkjaer L, Hammarström L, Andersen V et al. Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol 2002; 130: 495500.
  • 4
    Ferrer JM, Iglesias J, Hernandez M, Matamoros N. Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients. Clin Exp Immunol 1995; 102: 2869.
  • 5
    Thon V, Wolf HM, Sasgary M et al. Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients. Clin Exp Immunol 1997; 110: 17481.
  • 6
    Thon V, Eggenbauer H, Wolf HM et al. Antigen presentation by common variable immunodeficiency (CVID) B cells and monocytes is unimpaired. Clin Exp Immunol 1997; 108: 18.
  • 7
    Holm AM, Aukrust P, Aandahl EM, Muller F, Tasken K, Fröland SS. Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency involvement of protein kinase A type I. J Immunol 2003; 170: 57727.
  • 8
    North ME, Webster AD, Farrant J. Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ (‘cytotoxic’) and CD28(‘suppressor’) CD8+ subsets. Clin Exp Immunol 1998; 111: 705.
  • 9
    Punnonen J, Kainulainen L, Ruuskanen O, Nikoskelainen J, Arvilommi H. IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency. Scand J Immunol 1997; 45: 20312.
  • 10
    Baumert E, Wolff-Vorbeck G, Schlesier M, Peter HH. Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID). Clin Exp Immunol 1992; 90: 2530.
  • 11
    Nordoy I, Muller F, Aukrust P, Fröland SS. Adhesion molecules in common variable immunodeficiency (CVID) − a decrease in l-selectin-positive T lymphocytes. Clin Exp Immunol 1998; 114: 25863.
  • 12
    Farrant J, Spickett G, Matamoros N et al. Study of B and T cell phenotypes in blood from patients with common variable immunodeficiency (CVID). Immunodeficiency 1994; 5: 15969.
  • 13
    Guazzi V, Aiuti F, Mezzaroma I et al. Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles. Clin Exp Immunol 2002; 129: 34653.
  • 14
    Brouet JC, Chedeville A, Fermand JP, Royer B. Study of the B cell memory compartment in common variable immunodeficiency. Eur J Immunol 2000; 30: 251620.
  • 15
    Agematsu K, Futatani T, Hokibara S et al. Absence of memory B cells in patients with common variable immunodeficiency. Clin Immunol 2002; 103: 3442.
  • 16
    Warnatz K, Denz A, Drager R et al. Severe deficiency of switched memory B cells (CD27(+) IgM(−) IgD(−) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 2002; 99: 154451.
  • 17
    Ferry BL, Jones EA, Bateman EA et al. Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method. Clin Exp Immunol 2005; 140: 5329.
  • 18
    Piqueras B, Lavenu-Bombled C, Galicier L et al. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J Clin Immunol 2003; 23: 385400.
  • 19
    Winer BJ, Brown DR, Michels KM. Statistical principles in experimental design, 3nd edn. New York: McGraw-Hill, 1991.
  • 20
    Van Baarle D, Kostense S, Van Oers MH, Hamann D, Miedema F. Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue. Trends Immunol 2002; 23: 58691.
  • 21
    Brenchley JM, Karandikar NJ, Betts MR et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101: 271120.
  • 22
    Bofill M, Borthwick NJ. CD38 in health and disease. Chem Immunol 2000; 75: 21834.
  • 23
    Mullighan CG, Read SJ, Bird AG, Kurtz JB, Chapel HM, Welsh KI. Human cytomegalovirus infection is not increased in common variable immunodeficiency. J Clin Immunol 1996; 16: 2727.
  • 24
    Kainulainen L, Nikoskelainen J, Vuorinen T, Tevola K, Liippo K, Ruuskanen O. Viruses and bacteria in bronchial samples from patients with primary hypogammaglobulinemia. Am J Respir Crit Care Med 1999; 159: 1199204.
  • 25
    Caruso AS, Licenziati M, Corulli AD et al. Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry 1997; 27: 716.
  • 26
    Horgan KJ, Luce GE, Tanaka Y et al. Differential expression of VLA-alpha 4 and VLA-beta 1 discriminates multiple subsets of CD4+CD45R0+‘memory’ T cells. J Immunol 1992; 149: 40827.
  • 27
    Bradley LM, Watson SR, Swain SL. Entry of naive CD4 T cells into peripheral lymph nodes requires l-selectin. J Exp Med 1994; 180: 24016.
  • 28
    Colonna-Romano G, Bulati M, Aquino A et al. B cells in the aged: Cd27, Cd5, and CD40 expression. Mech Ageing Dev 2003; 124: 38993.
  • 29
    Nijhuis EW, Remarque EJ, Hinloopen B et al. Age-related increase in the fraction of CD27CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo. Clin Exp Immunol 1994; 96: 52834.