Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation


Laura Ferrero-Miliani, Research Laboratory of Gastroenterology 54 O3, Herlev Hospital, University of Copenhagen, Herlev Ringvej, DK-2730 Herlev, Denmark.


Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process − which under normal conditions is self-limiting − becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle–Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-κB, transcription, production and secretion of interleukin (IL)-1β and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.