• 1
    Pena M, Bacallao J. Malnutrition and poverty. Annu Rev Nutr 2002; 22:24153.
  • 2
    Rice AL, Sacco L, Hyder A, Black RE. Malnutrition as an underlying cause of childhood deaths associated with infectious diseases in developing countries. Bull World Health Organ 2000; 78:120721.
  • 3
    Cravioto J, Arrieta R. Nutrition, mental development, behaviour and learning, 2nd edn. México: INCYTAS-DIF, 1985.
  • 4
    Ortiz R, Cortés E, Pérez L, González C, Betancourt M. Assessment of an experimental method to induce malnutrition by food competition during lactation. Med Sci Res 1996; 24:8436.
  • 5
    Winick M, Noble A. Cellular response in rats during malnutrition at various ages. J Nutr 1966; 89:3006.
  • 6
    Galler JR, Kanis KB. Animal models of malnutrition applied to brain research. Curr Top Nutr Dis 1987; 16:5773.
  • 7
    Gómez F. Malnutrition. Bol Med Hosp Infant Mex 1946; 3:54351.
  • 8
    Betancourt M, Ortiz R, Gonzalez C. Proliferation index in bone marrow cells from severely malnourished rats during lactation. Mutat Res 1992; 283:1737.
  • 9
    Gómez JL, Campos C, Rangel P, Ortiz R. Cell cycle phase duration in bone marrow cells from malnourished rats during suckling. Mutat Res 1996; 352:5760.
  • 10
    Ortiz R, Cortés L, González-Marquez H, Gómez JL, González C, Cortés E. Flow cytometric analysis of spontaneous and dexamethasone-induced apoptosis in thymocytes from severely malnourished rats. Br J Nutr 2001; 86:5458.
  • 11
    Keusch GT. The history of nutrition: malnutrition, infection and immunity. J Nutr 2003; 133:336S40S.
  • 12
    Scrimshaw NS. Historical concepts of interactions, synergism and antagonism between nutrition and infection. J Nutr 2003; 133:316S21S.
  • 13
    Schroeder DG, Brown KH. Nutritional status as a predictor of child survival: summarizing the association and quantifying its global impact. Bull World Health Organ 1994; 72:56979.
  • 14
    Flo J, Massouh EJ, Roux ME. Long term effects of malnutrition during lactation on GALT. Reg Immunol 1993; 5:1005.
  • 15
    Flo J, Elias F, Massouh E, Roux ME. Impairment of B and T cell maturation in gut associated lymphoid tissues due to malnutrition during lactation. Dev Comp Immunol 1994; 18:54355.
  • 16
    Woodward B, Hillyer L, Hunt K. T cells with a quiescent phenotype (CD45RA+) are overabundant in the blood and involuted lymphoid tissues in wasting protein and energy deficiencies. Immunology 1999; 96:24653.
  • 17
    Chowdhury FA, Miah RA, Begum M, Rahman KM. The transformation in vitro of peripheral lymphocytes of malnourished children. Bangladesh Med Res Counc Bull 1993; 19:6770.
  • 18
    Nájera O, González C, Toledo G et al. Early activation of T, B and NK lymphocytes in infected malnourished and infected well-nourished children. J Nutr Immunol 2001; 5:8597.
  • 19
    Rodriguez L, Gonzalez C, Flores L, Jimenez-Zamudio L, Graniel J, Ortiz R. Assessment by flow cytometry of cytokine production in malnourished children. Clin Diagn Lab Immunol 2005; 12:5027.
  • 20
    Von Andrian UH, Sallusto F. Lymphocyte activation. Curr Opin Immunol 2007; 19:2478.
  • 21
    Cantrell DA. Regulation and function of serine kinase networks in lymphocytes. Curr Opin Immunol 2003; 15:2948.
  • 22
    Pighetti GM, Eskew ML, Reddy CC, Sordillo LM. Selenium and vitamin E deficiency impair transferrin receptor internalization but not IL-2, IL-2 receptor, or transferrin receptor expression. J Leukoc Biol 1998; 63:1317.
  • 23
    Neckers LM, Cossman J. Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2. Proc Natl Acad Sci USA 1983; 80:34948.
  • 24
    Campbell DI, Murch SH, Elia M et al. Chronic T cell-mediated enteropathy in rural west African children: relationship with nutritional status and small bowel function. Pediatr Res 2003; 54:30611.
  • 25
    Si MS, Reitz BA, Borie DC. Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123. Invest New Drugs 2005; 23:219.
  • 26
    Barten MJ, Gummert JF, Van Gelder T, Shorthouse R, Morris RE. Flow cytometric quantitation of calcium-dependent and -independent mitogen-stimulation of T cell functions in whole blood: inhibition by immunosuppressive drugs in vitro. J Immunol Meth 2001; 253:95112.
  • 27
    Laso FJ, Madruga JI, San Miguel JF et al. Long lasting immunological effects of ethanol after withdrawal. Cytometry 1996; 26:27580.
  • 28
    Ortiz R, Cortes E, Gonzalez C, Perez L, Betancourt M. Micronucleus frequency in spleen lymphocytes from severely malnourished rats during lactation. Environ Mol Mutagen 1995; 26:559.
  • 29
    Boule NG, Tremblay A, Gonzalez-Barranco J et al. Insulin resistance and abdominal adiposity in young men with documented malnutrition during the first year of life. Int J Obes Relat Metab Disord 2003; 27:598604.
  • 30
    Godinez-Fernandez R, Leehan JA, Fierro-Pastrana R, Ortiz-Muniz R. Effect of malnutrition on K+ current in T lymphocytes. Clin Diagn Lab Immunol 2005; 12:80813.
  • 31
    Cunha WD, Friedler G, Vaisberg M, Egami MI, Costa Rosa LF. Immunosuppression in undernourished rats: the effect of glutamine supplementation. Clin Nutr 2003; 22:4537.
  • 32
    Bossuyt PJ, Rector ES, Taylor CG. Dietrary zinc deficiency and protein–energy malnutrition decrease in vitro murine T lymphocytes cell cycle. J Nutr Immunol 2001; 5:7184.
  • 33
    Zhao Z, Ross AC. Retinoic acid repletion restores the number of leukocytes and their subsets and stimulates natural cytotoxicity in vitamin A-deficient rats. J Nutr 1995; 125:206473.
  • 34
    Bala S, Failla ML, Lunney JK. Alterations in splenic lymphoid cell subsets and activation antigens in copper-deficient rats. J Nutr 1991; 121:74553.
  • 35
    Anstead GM, Chandrasekar B, Zhao W, Yang J, Perez LE, Melby PC. Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect Immun 2001; 69:470918.
  • 36
    Green ED, Baenziger JU. Oligosaccharide specificities of Phaseolus vulgaris leukoagglutinating and erythroagglutinating phytohemagglutinins. Interactions with N-glycanase-released oligosaccharides. J Biol Chem 1987; 262:1201829.
  • 37
    Chilson OP, Kelly-Chilson AE. Mitogenic lectins bind to the antigen receptor on human lymphocytes. Eur J Immunol 1989; 19:38996.
  • 38
    Kontny E. Surface markers on human activated T lymphocytes. II. CD4 and CD8 differentiation antigens. Arch Immunol Ther Exp (Warsz) 1989; 37:56976.
  • 39
    Antonaci S, Tortorella C, Polignano A, Ottolenghi A, Jirillo E, Bonomo L. Modulating effects on CD25 and CD71 antigen expression by lectin-stimulated T lymphocytes in the elderly. Immunopharmacol Immunotoxicol 1991; 13:87100.
  • 40
    Giordano C, De Maria R, Todaro M et al. Study of T-cell activation in type I diabetic patients and pre-type I diabetic subjects by cytometric analysis: antigen expression defect in vitro. J Clin Immunol 1993; 13:6878.
  • 41
    Meier P, Dayer E, Ronco P, Blanc E. Dysregulation of IL-2/IL-2R system alters proliferation of early activated CD4+ T cell subset in patients with end-stage renal failure. Clin Nephrol 2005; 63:821.
  • 42
    Seiser C, Teixeira S, Kuhn LC. Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA. J Biol Chem 1993; 268:1307480.
  • 43
    Salmeron A, Borroto A, Fresno M, Crumpton MJ, Ley SC, Alarcon B. Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain. J Immunol 1995; 154:167583.
  • 44
    Batista A, Millan J, Mittelbrunn M, Sanchez-Madrid F, Alonso MA. Recruitment of transferrin receptor to immunological synapse in response to TCR engagement. J Immunol 2004; 172:670914.
  • 45
    Ellery JM, Nicholls PJ. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev 2002; 13:2740.
  • 46
    McMurray DN, Bartow RA. Immunosuppression and alteration of resistance to pulmonary tuberculosis in guinea pigs by protein undernutrition. J Nutr 1992; 122:73843.
  • 47
    Dai G, McMurray DN. Altered cytokine production and impaired antimycobacterial immunity in protein-malnourished guinea pigs. Infect Immun 1998; 66:35628.
  • 48
    Najera O, Gonzalez C, Toledo G et al. Early activation of T, B and NK lymphocytes in infected malnourished and infected well-nourished children. J Nutr Immunol 2001; 5:8597.
  • 49
    Hunter CA, Reiner SL. Cytokines and T cells in host defense. Curr Opin Immunol 2000; 12:41318.
  • 50
    McMurray DN, Loomis SA, Casazza LJ, Rey H, Miranda R. Development of impaired cell-mediated immunity in mild and moderate malnutrition. Am J Clin Nutr 1981; 34:6877.
  • 51
    Pelletier DL, Frongillo EA Jr, Schroeder DG, Habicht JP. A methodology for estimating the contribution of malnutrition to child mortality in developing countries. J Nutr 1994; 124:S210622.
  • 52
    Nájera O, González C, Betancourt M, Ortiz R. Malnutrition in Mexico: revision of government programme and the diagnostic studies of national reach. Bol Med Hosp Infant Mex 2001; 58:12033.