1365-2249/asset/cei_left.gif?v=1&s=ffee144c532fe5e73bbb89290ba14e154b0d400b)
1365-2249/asset/cei_right.gif?v=1&s=c14d545a5215173707c8202758d5b25fd0bede44)
You have full text access to this OnlineOpen article
Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model
Article first published online: 26 SEP 2008
DOI: 10.1111/j.1365-2249.2008.03772.x
© 2008 British Society for Immunology
Additional Information
How to Cite
Yamagata, S., Tomita, K., Sato, R., Niwa, A., Higashino, H. and Tohda, Y. (2008), Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model. Clinical & Experimental Immunology, 154: 295–304. doi: 10.1111/j.1365-2249.2008.03772.x
Publication History
- Issue published online: 5 NOV 2008
- Article first published online: 26 SEP 2008
- Accepted for publication 13 August 2008
References
- 1, , . Biopsy markers of airway inflammation and remodelling. Respir Med 2000; 94:S9–15.
- 2, , et al. Antioxidant down-regulates interleukin-18 expression in asthma. Mol Pharmacol 2006; 70:1184–93.
- 3, , et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378:88–91.
- 4, , , . Differential roles of IL-18 in allergic airway disease: induction of eotaxin by resident cell populations exacerbates eosinophil accumulation. J Immunol 2000; 164:1096–102.
- 5, , , , . In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells. Eur J Immunol 2000; 30:1998–2006.Direct Link:
- 6, , , , , . Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse. J Exp Med 2004; 199:535–45.
- 7, , , , . IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1- and Th2-cytokines and IL-8. Int Immunol 2004; 16:1733–9.
- 8, , et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142:434–57.
- 9, , et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis 1993; 148:713–19.
- 10, , , , , . Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997; 156:737–43.
- 11, , , . Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995; 95:843–52.
- 12, , et al. Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice. Am J Physiol Lung Cell Mol Physiol 2001; 280:L565–73.
- 13, , et al. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol 2004; 30:651–61.
- 14, , et al. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 2004; 113:551–60.
- 15, , , , , . Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice. Am J Physiol Lung Cell Mol Physiol 2006; 291:L265–71.
- 16, . Mouse model of airway remodeling: strain differences. Am J Respir Crit Care Med 2003; 168:959–67.
- 17
- 18, , et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160:1001–8.
- 19, , , , , . T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production. Proc Natl Acad Sci USA 2007; 104:14765–70.
- 20, , et al. IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice. J Allergy Clin Immunol 2000; 105:45–53.
- 21, . Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation. Pharmacol Ther 2002; 94:185–211.
- 22, . Role of cytokines in allergic airway inflammation. Int Arch Allergy Immunol 2007; 142:265–73.
- 23, , , , . Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989; 320:271–7.
- 24, , et al. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 1994; 24:73–80.
- 25, , , , . IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand. Int Immunol 1993; 5:657–63.
- 26, , et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993; 90:3730–4.
- 27, , et al. Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma. Am J Respir Cell Mol Biol 2002; 26:484–90.
- 28, , , , . Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. Am J Physiol Lung Cell Mol Physiol 2004; 287:L119–26.
- 29, , . Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 1998; 53:21–7.
- 30, , et al. Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest 1997; 112:45–52.
- 31, , , , , . Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997; 111:852–7.
- 32, , et al. Pathological changes according to the severity of asthma. Clin Exp Allergy 1996; 26:1210–19.
- 33, . Murine model of chronic human asthma. Immunol Cell Biol 2001; 79:141–4.Direct Link:
- 34, . Modeling allergic asthma in mice: pitfalls and opportunities. Am J Respir Cell Mol Biol 2002; 27:267–72.
- 35, , . Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment. Am J Physiol Lung Cell Mol Physiol 2000; 279:L1120–8.
- 36, , , , , . Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy 2003; 33:1711–16.
- 37, , . Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle. Am J Respir Crit Care Med 2004; 169:596–603.
- 38, , et al. Local synthesis of epsilon germline gene transcripts, IL-4, and IL-13 in allergic nasal mucosa after ex vivo allergen exposure. J Allergy Clin Immunol 2000; 106:46–52.
- 39, , , , . Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002; 282:L226–36.
- 40, , et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282:2258–61.
- 41, , et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:2261–3.
- 42, , et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001; 167:4668–75.
- 43, , et al. Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. J Allergy Clin Immunol 2003; 111:1361–9.
- 44, . Interleukin-13-dependent bronchial hyper-responsiveness following isolated upper-airway allergen challenge in a murine model of allergic rhinitis and asthma. Clin Exp Allergy 2005; 35:1104–11.
- 45, , et al. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling. Cytokine 2004; 28:224–32.
- 46, , , , . Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice? Am J Respir Crit Care Med 2004; 170:851–6.
- 47, , et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997; 156:591–9.
- 48, , , , . Effects of anticytokine therapy in a mouse model of chronic asthma. Am J Respir Crit Care Med 2004; 170:1043–8.
- 49, . Prolonged allergen challenge in mice leads to persistent airway remodelling. Clin Exp Allergy 2004; 34:497–507.
- 50, , et al. Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model. Am J Pathol 1999; 154:1911–21.
- 51, , , , . An essential role for IL-18 in CD8 T cell-mediated suppression of IgE responses. J Immunol 2007; 178:4771–8.
- 52, , , , . The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma. Clin Exp Allergy 1999; 29:90–5.
- 53, , et al. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol 2007; 178:1948–59.
- 54, , . Asthma and cigarette smoking. Eur Respir J 2004; 24:822–33.
- 55, , , , , . Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 1999; 160:1532–9.