Clinical Immunology Review Series: An approach to the management of pulmonary disease in primary antibody deficiency


  • Series Originator: Edward Kaminski Series Editor: Stephen Jolles

H. J. Longhurst, Department of Clinical Immunology, Royal London Hospital, Pathology and Pharmacy Building, 80 Newark Street, Whitechapel E1 1BB, UK.


The sinopulmonary tract is the major site of infection in patients with primary antibody deficiency syndromes, and structural lung damage arising from repeated sepsis is a major determinant of morbidity and mortality. Patients with common variable immunodeficiency may, in addition, develop inflammatory lung disease, often associated with multi-system granulomatous disease. This review discusses the presentation and management of lung disease in patients with primary antibody deficiency.