Clinical Immunology Review Series: An approach to the management of pulmonary disease in primary antibody deficiency

Authors


  • Series Originator: Edward Kaminski Series Editor: Stephen Jolles

H. J. Longhurst, Department of Clinical Immunology, Royal London Hospital, Pathology and Pharmacy Building, 80 Newark Street, Whitechapel E1 1BB, UK.
E-mail: hilary.longhurst@bartsandthelondon.nhs.uk

Summary

The sinopulmonary tract is the major site of infection in patients with primary antibody deficiency syndromes, and structural lung damage arising from repeated sepsis is a major determinant of morbidity and mortality. Patients with common variable immunodeficiency may, in addition, develop inflammatory lung disease, often associated with multi-system granulomatous disease. This review discusses the presentation and management of lung disease in patients with primary antibody deficiency.

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