SEARCH

SEARCH BY CITATION

Keywords:

  • agammaglobulinaemia;
  • common variable immunodeficiency;
  • interstitial;
  • lung disorders;
  • pneumonia;
  • ronchiectasis

Summary

The sinopulmonary tract is the major site of infection in patients with primary antibody deficiency syndromes, and structural lung damage arising from repeated sepsis is a major determinant of morbidity and mortality. Patients with common variable immunodeficiency may, in addition, develop inflammatory lung disease, often associated with multi-system granulomatous disease. This review discusses the presentation and management of lung disease in patients with primary antibody deficiency.