Immune regulation by non-lymphoid cells in transplantation

Authors

  • A.-S. Dugast,

    1. INSERM, U643, Nantes,
    2. CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, and
    3. Université de Nantes, Faculté de Médecine, Nantes, F44093 France
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  • B. Vanhove

    1. INSERM, U643, Nantes,
    2. CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, and
    3. Université de Nantes, Faculté de Médecine, Nantes, F44093 France
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Dr B. Vanhove, ITERT, INSERM U643, CHU Hôtel Dieu, 30 Bd Jean Monnet, 44093 Nantes, France.
E-mail: bernard.vanhove@univ-nantes.fr

Summary

Regulatory cells play a crucial role in the induction and maintenance of tolerance by controlling T cell as well as B and natural killer (NK) cell-mediated immunity. In transplantation, CD4+CD25+forkhead box P3+ T regulatory cells are instrumental in the maintenance of immunological tolerance, as are several other T cell subsets such as NK T cells, double negative CD3+ T cells, γδ T cells, interleukin-10-producing regulatory type 1 cells, transforming growth factor-β-producing T helper type 3 cells and CD8+CD28- cells. However, not only T cells have immunosuppressive properties, as it is becoming increasingly clear that both T and non-T regulatory cells co-operate and form a network of cellular interactions controlling immune responses. Non-T regulatory cells include tolerogenic dendritic cells, plasmacytoid dendritic cells, mesenchymal stem cells, different types of stem cells, various types of alternatively activated macrophages and myeloid-derived suppressor cells. Here, we review the mechanism of action of these non-lymphoid regulatory cells as they relate to the induction or maintenance of tolerance in organ transplantation.

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