• 1
    Cooper PJ, Chico ME, Sandoval C, Nutman TB. Atopic phenotype is an important determinant of immunoglobulin E-mediated inflammation and expression of T helper cell type 2 cytokines to Ascaris antigens in children exposed to ascariasis. J Infect Dis 2004; 190:133846.
  • 2
    Kennedy MW, Fraser EM, Christie JF. MHC class II (I-A) region control of the IgE antibody repertoire to the ABA-1 allergen of the nematode Ascaris. Immunology 1991; 72:5779.
  • 3
    Holland CV, Crompton DW, Asaolu SO, Crichton WB, Torimiro SE, Walters DE. A possible genetic factor influencing protection from infection with Ascaris lumbricoides in Nigerian children. J Parasitol 1992; 78:91516.
  • 4
    Bundy DA. Population ecology of intestinal helminth infections in human communities. Phil Trans R Soc Lond B Biol Sci 1988; 321:40520.
  • 5
    Peisong G, Yamasaki A, Mao XQ et al. An asthma-associated genetic variant of STAT6 predicts low burden of Ascaris worm infestation. Genes Immun 2004; 5:5862.
  • 6
    Ramsay CE, Hayden CM, Tiller KJ et al. Association of polymorphisms in the beta2-adrenoreceptor gene with higher levels of parasitic infection. Hum Genet 1999; 104:26974.
  • 7
    Moller M, Gravenor MB, Roberts SE, Sun D, Gao P, Hopkin JM. Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms. Hum Mol Genet 2007; 16:182836.
  • 8
    Forrester JE, Scott ME, Bundy DA, Golden MH. Predisposition of individuals and families in Mexico to heavy infection with Ascaris lumbricoides and Trichuris trichiura. Trans R Soc Trop Med Hyg 1990; 84:2726.
  • 9
    Williams-Blangero S, Subedi J, Upadhayay RP et al. Genetic analysis of susceptibility to infection with Ascaris lumbricoides. Am J Trop Med Hyg 1999; 60:9216.
  • 10
    Nejsum P, Roepstorff A, Jorgensen CB et al. High heritability for Ascaris and Trichuris infection levels in pigs. Heredity 2009; 102:35764.
  • 11
    Williams-Blangero S, VandeBerg JL, Subedi J et al. Genes on chromosomes 1 and 13 have significant effects on Ascaris infection. Proc Natl Acad Sci USA 2002; 99:55338.
  • 12
    Williams-Blangero S, Vandeberg JL, Subedi J, Jha B, Correa-Oliveira R, Blangero J. Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. J Infect Dis 2008; 197:6671.
  • 13
    Lewis R, Behnke JM, Cassidy JP, Stafford P, Murray N, Holland CV. The migration of Ascaris suum larvae, and the associated pulmonary inflammatory response in susceptible C57BL/6j and resistant CBA/Ca mice. Parasitology 2007; 134:130114.
  • 14
    Hagel I, Cabrera M, Buvat E et al. Antibody responses and resistance against Ascaris lumbricoides infection among Venezuelan rural children: the influence of ethnicity. J Trop Pediatr 2008; 54:3546.
  • 15
    McSharry C, Xia Y, Holland CV, Kennedy MW. Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children. Infect Immun 1999; 67:4849.
  • 16
    Hagel I, Lynch NR, Perez M, Di Prisco MC, Lopez R, Rojas E. Relationship between the degree of poverty and the IgE response to Ascaris infection in slum children. Trans R Soc Trop Med Hyg 1993; 87:1618.
  • 17
    Hagel I, Lynch NR, Puccio F et al. Defective regulation of the protective IgE response against intestinal helminth Ascaris lumbricoides in malnourished children. J Trop Pediatr 2003; 49:13642.
  • 18
    Hagel I, Lynch NR, Di Prisco MC, Rojas E, Perez M, Alvarez N. Ascaris reinfection of slum children: relation with the IgE response. Clin Exp Immunol 1993; 94:803.
  • 19
    Turner JD, Faulkner H, Kamgno J et al. IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection. Microbes Infect 2005; 7:9906.
  • 20
    Caraballo LR, Marrugo J, Erlich H, Pastorizo M. HLA alleles in the population of Cartagena (Colombia). Tissue Antigens 1992; 39:12833.
  • 21
    Builes JJ, Martinez B, Gomez A et al. Y chromosome STR haplotypes in the Caribbean city of Cartagena (Colombia). Forensic Sci Int 2007; 167:629.
  • 22
    Caraballo L, Cadavid A, Mendoza J. Prevalence of asthma in a tropical city of Colombia. Ann Allergy 1992; 68:5259.
  • 23
    Dennis R, Caraballo L, Garcia E et al. Asthma and other allergic conditions in Colombia: a study in 6 cities. Ann Allergy Asthma Immunol 2004; 93:56874.
  • 24
    Martinez B, Barrios K, Vergara C et al. A NOS1 gene polymorphism associated with asthma and specific immunoglobulin E response to mite allergens in a Colombian population. Int Arch Allergy Immunol 2007; 144:10513.
  • 25
    Acevedo N, Vergara C, Mercado D, Jimenez S, Caraballo L. The A-444C polymorphism of leukotriene C4 synthase gene is associated with IgE antibodies to Dermatophagoides pteronyssinus in a Colombian population. J Allergy Clin Immunol 2007; 119:5057.
  • 26
    Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
  • 27
    Clarke DH, Casals J. Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. Am J Trop Med Hyg 1958; 7:56173.
  • 28
    Abebe W, Tsuji N, Kasuga-Aoki H et al. Species-specific proteins identified in Ascaris lumbricoides and Ascaris suum using two-dimensional electrophoresis. Parasitol Res 2002; 88:86871.
  • 29
    Puerta L, Fernandez-Caldas E, Lockey RF, Caraballo LR. Mite allergy in the tropics: sensitization to six domestic mite species in Cartagena, Colombia. J Invest Allergol Clin Immunol 1993; 3:198204.
  • 30
    Christie JF, Dunbar B, Kennedy MW. The ABA-1 allergen of the nematode Ascaris suum: epitope stability, mass spectrometry, and N-terminal sequence comparison with its homologue in Toxocara canis. Clin Exp Immunol 1993; 92:12532.
  • 31
    Xia Y, Spence HJ, Moore J et al. The ABA-1 allergen of Ascaris lumbricoides: sequence polymorphism, stage and tissue-specific expression, lipid binding function, and protein biophysical properties. Parasitology 2000; 120:21124.
  • 32
    Moore J, McDermott L, Price NC, Kelly SM, Cooper A, Kennedy MW. Sequence-divergent units of the ABA-1 polyprotein array of the nematode Ascaris suum have similar fatty-acid- and retinol-binding properties but different binding-site environments. Biochem J 1999; 340:33743.
  • 33
    Puerta Llerena L, Fernandez-Caldas E, Caraballo Gracia LR, Lockey RF. Sensitization to Blomia tropicalis and Lepidoglyphus destructor in Dermatophagoides spp-allergic individuals. J Allergy Clin Immunol 1991; 88:94350.
  • 34
    Chew FT, Lim SH, Goh DY, Lee BW. Sensitization to local dust-mite fauna in Singapore. Allergy 1999; 54:11509.
  • 35
    Ferrandiz R, Casas R, Dreborg S. Sensitization to Dermatophagoides siboney, Blomia tropicalis, and other domestic mites in asthmatic patients. Allergy 1996; 51:5015.
  • 36
    Caraballo L, Puerta L, Fernandez-Caldas E, Lockey RF, Martinez B. Sensitization to mite allergens and acute asthma in a tropical environment. J Invest Allergol Clin Immunol 1998; 8:2814.
  • 37
    Vergara C, Caraballo L, Mercado D et al. African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia. Hum Genet 2009 (in press).
  • 38
    Agudelo-Lopez SG-RL, Coronado X, Orozco A et al. Prevalence of intestinal parasitism and associated factors in a village on the Colombian Atlantic Coast. Rev Salud Publica 2008; 10:63342.
  • 39
    Fernandez-Caldas E, Puerta L, Mercado D, Lockey RF, Caraballo LR. Mite fauna, Der p I, Der f I and Blomia tropicalis allergen levels in a tropical environment. Clin Exp Allergy 1993; 23:2927.
  • 40
    Puerta L, Fernandez-Caldas E, Mercado D, Lockey RF, Caraballo LR. Sequential determinations of Blomia tropicalis allergens in mattress and floor dust samples in a tropical city. J Allergy Clin Immunol 1996; 97:68991.
  • 41
    Fernandez-Caldas E, Puerta L, Caraballo L, Mercado D, Lockey RF. Sequential determinations of Dermatophagoides spp. allergens in a tropical city. J Invest Allergol Clin Immunol 1996; 6:98102.
  • 42
    Caraballo L, Mercado D, Vergara C, Fernández A, Gutiérrez M. High prevalence of IgE antibodies to Ascaris in asthmatic patients living in a tropical environment. J Allergy Clin Immunol 2007; 119:S210.
  • 43
    Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell 1998; 2:47784.
  • 44
    Pan-Hammarstrom Q, Jones AM, Lahdesmaki A et al. Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J Exp Med 2005; 201:18994.
  • 45
    Girard PM, Kysela B, Harer CJ, Doherty AJ, Jeggo PA. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum Mol Genet 2004; 13:236976.
  • 46
    Moore PA, Belvedere O, Orr A et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285:2603.
  • 47
    Smirnova AS, Andrade-Oliveira V, Gerbase-DeLima M. Identification of new splice variants of the genes BAFF and BCMA. Mol Immunol 2008; 45:117983.
  • 48
    Gavin AL, Duong B, Skog P et al. deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models. J Immunol 2005; 175:31928.
  • 49
    Chatila TA. Interleukin-4 receptor signaling pathways in asthma pathogenesis. Trends Mol Med 2004; 10:4939.
  • 50
    Kelly-Welch AE, Wang HY, Wang LM et al. Transgenic expression of insulin receptor substrate 2 in murine B cells alters the cell density-dependence of IgE production in vitro and enhances IgE production in vivo. J Immunol 2004; 172:280310.
  • 51
    Hunninghake GM, Lasky-Su J, Soto-Quiros ME et al. Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. Am J Respir Crit Care Med 2008; 177:8306.
  • 52
    Dold S, Heinrich J, Wichmann HE, Wjst M. Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany. J Allergy Clin Immunol 1998; 102:41420.
  • 53
    Karadag B, Ege M, Bradley JE et al. The role of parasitic infections in atopic diseases in rural schoolchildren. Allergy 2006; 61:9961001.
  • 54
    Roepstorff A. Natural Ascaris suum infections in swine diagnosed by coprological and serological (ELISA) methods. Parasitol Res 1998; 84:53743.
  • 55
    Mitre E, Nutman TB. IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections. J Allergy Clin Immunol 2006; 117:93945.
  • 56
    Acevedo N, Sanchez J, Fernandez A. et al. IgE cross-reactivity between Ascaris and domestic mites: the role of fatty acid binding proteins allergens and the panallergen tropomyosin. Allergy 2007; 62:300.
  • 57
    Van Riet E, Wuhrer M, Wahyuni S et al. Antibody responses to Ascaris-derived proteins and glycolipids: the role of phosphorylcholine. Parasite Immunol 2006; 28:36371.
  • 58
    Frontera E, Carron A, Serrano FJ, Roepstorff A, Reina D, Navarrete I. Specific systemic IgG1, IgG2 and IgM responses in pigs immunized with infective eggs or selected antigens of Ascaris suum. Parasitology 2003; 127:2918.
  • 59
    Obihara CC, Beyers N, Gie RP et al. Respiratory atopic disease, Ascaris-immunoglobulin E and tuberculin testing in urban South African children. Clin Exp Allergy 2006; 36:6408.